炎症因子及脂肪因子参与类风湿关节炎并发心血管疾病的研究进展

Advances in Inflammatory Factors and Adipokines Involved in Rheumatoid Arthritis Complicated with Cardiovascular Disease

类风湿关节炎(RA)是一种慢性自身免疫性疾病,其病理特点为侵蚀性、对称性关节滑膜炎。RA慢性炎症增加了心血管疾病发病率,其中血管慢性炎症导致动脉粥样硬化是RA患者主要并发症。血管慢性炎症涉及许多炎症免疫细胞、炎症因子和脂肪因子等。在RA患者体内,高水平炎性因子如C反应蛋白、肿瘤坏死因子-α、白细胞介素6等,加速动脉粥样硬化以及心肌纤维化。一些脂肪因子,如脂联素、瘦素、抵抗素等也是引起RA患者并发心血管疾病的重要因素。该文对近年来关于炎症因子及脂肪因子参与RA伴发的心血管疾病的研究进展进行综述。

Rheumatoid arthritis(RA)is a chronic autoimmune disease characterized by erosive and symmetric synovitis.Chronic inflammation of RA increases the incidence of cardiovascular disease.Atherosclerosis caused by inflammation in blood vessels is the main complication of RA patients.Many inflammatory immune cells,inflammatory factors,and adipokines were involved in chronic inflammation in vascular.In patients with RA,high levels of inflammatory factors,such as C reactive protein,tumor necrosis factorα,interleukin6,accelerated atherosclerosis and myocardial fibrosis.Some adipokines,including adiponectin,leptin and resistin,are also important factors causing cardiovascular diseases in patients with RA.In this paper,they review the research advances of inflammatory factors and adipokines involved in RA associated with cardiovascular disease.