纳米技术在寄生虫学中的应用

Application of Nanotechnology in Parasitology

纳米技术是20世纪80年代新兴发展起来的核心信息技术,广泛应用于生命医学、光电化工等领域。纳米技术与寄生虫病的试剂仪器诊断、药物治疗及疫苗防控环节有机结合,全面应用于纳米金标检测试纸条、试剂盒和仪器设备、纳米载体靶向驱虫药物、新型纳米疫苗佐剂的研发制备等方面,深入渗透到医学领域并广泛应用到寄生虫学中。作者着眼于当前纳米技术在寄生虫学中的应用,重点阐述了其在寄生虫病的检测诊断、驱虫药物和疫苗佐剂中的应用情况,包括胶体金标记免疫亲和层析、微粒材料合成、生物传感等纳米技术在寄生虫病检测诊断中的应用,总结了新型纳米驱虫药物脂质载体、化学合成药、草本中药研发的进展,并对疫苗佐剂研发中的热点,如纳米脂质体、聚合物颗粒、细胞因子的相关进展进行了概述。本文旨在为纳米技术在寄生虫学中的深入应用和研究提供参考。

Nanotechnology is the emerging development of the core information technology in the1980s,and it has been widely used in life medicine,optoelectronics and other fields.Nanotechnology is effectively combined with parasitic disease reagents instrumentation,drug treatment,vaccine prevention and control,and has a comprehensive application in the nano gold standard test strip test kit and equipment,nano carrier targeted anthelmintic drugs,new nano vaccine adjuvant of research and development,etc.It penetrates deeply into the medical field and is widely used in parasitology.With the starting point of the application of nanotechnology in parasitology,this paper focused on the pathogenic detection,anthelmintic drugs and vaccine adjuvants of parasitic diseases.The authors described the application of nano technology,such as colloidal gold labeled immunoaffinity chromatography,microparticle material synthesis and biosensing,in the diagnosis and diagnosis of parasitic pathogens.The progress of new nano insect repellent drug lipid carrier,chemical synthesis medicine and herbal medicine research and development had been discussed here,in addition to liposomes,polymer particles,and cytokines in vaccine adjuvants.This review could be expected as a reference for nanotechnology in in depth research and better application in parasitology.