比较地屈孕酮和黄体酮胶丸治疗先兆流产的临床疗效和安全性

The Clinical Efficacy and Safety Ofdydrogesterone and Progesterone Soft Capsules on the Treatment of Threatened Abortion

目的比较地屈孕酮和黄体酮胶丸治疗先兆流产的临床疗效和安全性。方法选取我院2014年7月~2016年7月收治的先兆流产患者84例为研究对象,使用随机数表法分为两组,对照组42例,观察组42例。对照组患者接受黄体酮胶丸治疗,观察组患者接受地屈孕酮治疗,对比两组患者治疗10w后治疗效果、血清P水平及药物不良反应情况。结果观察组治疗总有效、保胎成功率均优于对照组,差异显著(P<005);治疗后观察组血清P水平及药物不良反应情况均优于对照组,差异显著(P<005)。结论地屈孕酮治疗先兆流产的临床疗效及安全性优于黄体酮胶丸。

Objective To compare the clinical efficacy and safety of dydrogesterone and progesterone soft capsules on the treatment of threatened abortion Methods Eight four cases of patients with threatened abortion in our hospital from July2014to July2016were collected and divided into experimental group and control group,with each group42cases The patients in the control group received progesterone soft capsules treatment,and the patients in the experimental group received dydrogesterone treatment The therapeutic effect,serum P level and adverse drug reactions of two groups after10week’s treatment were compared Results The total effective treatment and the tocolysis success rate of experimental group were better than the control group,the difference was significant(P<005)The level of serum P and adverse drug reactions in the experimental group were better than those in the control group after treatment,the difference was significant(P<005)Conclusion In terms of the clinical efficacy and safety,dydrogesterone in the treatment of threatened abortion was better than progesterone soft capsules