生物样品中抗凝血杀鼠剂的色谱法分析萃取技术研究进展

Insight of the Extraction Technology for Anticoagulant Rodenticides in the Biological Samples Tested with Chromatography

抗凝血杀鼠剂包括香豆素类和茚满二酮类两种,由于使用广泛,人、畜中毒的情况时有发生。生物样品中抗凝血杀鼠剂的检测是近年来毒物分析领域研究的热点。本文对国内外生物样品中抗凝血杀鼠剂的色谱法分析萃取研究进展进行了综述,阐述了生物样品中抗凝血杀鼠剂的萃取净化技术,主要包括液-液萃取、固相萃取等方法。本文也总结了现有生物样品中抗凝血杀鼠剂的分离提取方法存在的问题,分析了今后相关分离提取技术的发展方向。

Anticoagulant rodenticides are commonly categorized into two classes,the coumarin and indandione.Sometimes,people and livestock are poisoned with these rodenticides,making it necessary for such chemicals to be detected in the biological samples when the involved cases occurred.This paper summarizes the domestic and foreign researches on extraction technique for anticoagulant rodenticides in the biological samples tested by chromatography,with the main focus on the extraction and purification of the anticoagulant rodenticides in biological samples.Extraction technique,systematically developed and studied for the analysis of anticoagulant rodenticides,primarily includes liquid-liquid extraction(LLE),solidphase extraction(SPE)and the others related.This paper also analyzes the problems of the current detection technologies,and proposes the potential future direction of technical innovation.An integration that combines the extraction,purification and enrichment into one suite will be very likely a good alternative since it tends to be easy to operate,cheaper and more accessible into getting the ion-exchange resins.