摘要
总结患者来源的胃癌异种移植模型(patient-derived xenograft model,PDX)制备中存在的主要问题,提出相应的解决方案。介绍胃癌PDX模型在靶向药物研究中的独特优势,提出在强调肿瘤个体化模型的同时,要善于运用共性研究思维,分析模型的基因型特征开展肿瘤靶向治疗研究。
In this paper,we summarize the major problems existing in establishing gastric cancer patient derived xenograft(PDX)models and its solutions,and introduce its advantages on screening targeted drugs.As many previous research emphasized on individual characteristics too much,we argue that we should pay more attention to the generality of what we are studying in order to analyze the genotype of PDX models before taking a targeted therapy.
作者
胡斌权
曹博
师长宏
HU Bin-quan;CAO Bo;SHI Chang-hong(the Fourth Military Medical University, Student Brigade, Xi’an710032, China;the Fourth Military Medical University Laboratory Animal Center, Xi’an710032)
出处
《中国实验动物学报》
CSCD
北大核心
2017年第6期643-647,共5页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金(No.31572340
No.31772546)
军队实验动物专项课题(No.SYDW2014-002)
关键词
胃癌
人源性异种移植模型
靶向药物
基因型特征
Gastric cancer
Patient derived xenografts(PDX) models
Targeted drugs
Genotype characteristics
