热毒宁注射液治疗医院获得性肺炎前后的外周血NLR和CRP的相关性

Correlation of Neutrophil-to-lymphcyte Ratio (NLR) and C-reactive Protein (CRP) in Treating Hospital-acquired Pneumonia (HAP) Patients with Reduning Injection before and after Therapy

目的探讨热毒宁注射液治疗医院获得性肺炎前、后的外周血NLR和CRP的相关性。方法入选的HAP患者共计100例,在治疗前、后行外周血全血细胞计数及分类检测和C反应蛋白(C-reactive protein,CRP)等检查。结果 (1)入选的HAP患者以男性老年人多见,平均年龄(70.74±15.00)岁,男∶女比为71∶29;(2)入选的HAP患者在治疗前、后比较发现外周血WBC、NC、LC、NLR和CRP均有显著差异(均P<0.05);(3)Spearman或Pearson相关性检验的结果为外周血NLR和血清CRP呈正相关(r或r_s=0.538,P<0.01)。结论热毒宁注射液治疗HAP患者有效,它不仅具有降低患者机体肺部的炎症反应,而且外周血NLR和血清CRP的正相关可能是其取效的关键。

Objective To investigate the correlation of NLR and CRP in treating HAP patients with Reduning injection before and after therapy.Methods One hundred HAP patients were enrolled.Peripheral blood of White blood count(WBC)and classification detection and CRP test were performed before and after therapy.Results(1)It was more common in the men aged(average age was70.74依15.00years old,male-female ratio was71to29).(2)Peripheral blood of WBC,neutrophil count(NC),1ymphocyte count(LC),neutrophilto-lymphcyte ratio(NLR)and C-reactive Protein(CRP)in hospital-acquired pneumonia patients were significant difference before and after therapy(all P<0.05).(3)Spearman or Pearson correlation analysis showed that NLR had positive correlation with CRP(r or rs=0.538,P<0.01).Conclusion Reduning injection could treat HAP patients effectively after therapy,which reflected it could lower pulmonary inflammation of the patients,and the positive correlation of NLR and CRP could further illustrate the key to the therapy.