维生素C联合维生素E对血液透析患者抗氧化力、炎症反应状态的影响

Effect of vitamin C combined with vitamin E on antioxidant capacity and inflammatory response in patients with hemodialysis

目的:探讨维生素C联合维生素E对血液透析患者抗氧化力、炎症反应状态的影响。方法:收集在本院接受血液透析治疗的尿毒症患者116例,随机分为对照组及观察组各58例。对照组接受维生素C干预、观察组接受维生素C联合维生素E干预。对比两组干预前及干预后6周时血清中抗氧化指标、促炎介质、抗炎介质含量的差异。结果:干预前,两组血清中抗氧化指标、促炎介质、抗炎介质含量的差异不显著。干预后,两组血清中SOD、GSH-PX、T-AOC的含量均高于治疗前,IL-1、IL-2、IL-6、IL-8、IL-4、IL-10、IL-13的含量均低于治疗前且观察组患者血清中SOD、GSH-PX、T-AOC的含量均高于对照组,IL-1、IL-2、IL-6、IL-8、IL-4、IL-10、IL-13的含量均低于对照组。结论:血液透析患者接受维生素C联合维生素E干预,可有效增强机体的抗氧化力并抑制全身炎症状态。

Objective:To study the effect of vitamin C combined with vitamin E on antioxidant capacity and inflammatory response in patients with hemodialysis.Methods:116patients with uremia who received hemodialysis in the hospital between December2014and January2017were collected and divided into control group and observation group by random number table,each with58cases.Control group received vitamin C intervention,and observation group received vitamin C combined with vitamin E intervention.The differences in serum levels of antioxidant indexes,pro-inflammatory mediators and anti-inflammatory mediators were compared between the two groups before intervention and6weeks after intervention.Results:Before intervention,serum levels of antioxidant indexes,pro-inflammatory mediators and anti-inflammatory mediators were not significantly different between the two groups.After intervention,serum SOD,GSH-PX and T-AOC levels of both groups of patients were higher than those before treatment while IL-1,IL-2,IL-6,IL-8,IL-4,IL-10and IL-13levels were lower than those before treatment,and serum SOD,GSH-PX and T-AOC levels of observation group were higher than those of control group while IL-1,IL-2,IL-6,IL-8,IL-4,IL-10and IL-13levels were lower than those of control group.Conclusion:Vitamin C combined with vitamin E intervention can effectively enhance the antioxidant capacity and suppress the systemic inflammatory state in patients with hemodialysis.