代谢综合征患儿血清E-FABP含量与糖脂代谢、内皮损伤及炎症反应的相关性

Correlation of serum E-FABP content with glucose lipid metabolism,endothelial injury and inflammatory response in children with metabolic syndrome

目的:探讨代谢综合征患儿血清E-FABP含量与糖脂代谢、内皮损伤及炎症反应的相关性。方法:收集在本院接受治疗的代谢综合征患儿49例(观察组),同期在本院进行疫苗注射的健康儿童50例(正常对照组)。检测两组研究对象血清中E-FABP、糖脂代谢、内皮损伤及炎症反应指标含量,采用Pearson检验评估E-FABP含量与糖脂代谢、内皮损伤及炎症反应的相关性。结果:观察组患儿血清中E-FABP的含量高于正常对照组小儿;外周血中糖代谢指标FBG、HOMA-IR的水平高于正常对照组小儿;外周血中脂质代谢指标TC、LDL-C、ApB的含量高于正常对照组小儿,HDL-C、ApA1的含量低于正常对照组小儿;血清中内皮损伤指标ET-1的含量高于正常对照组小儿,NO的含量低于正常对照组小儿;血清中炎症反应指标CRP、IL-1β、IL-6、IL-17的含量高于正常对照组小儿(P<0.05)。经Pearson检验发现,代谢综合征患儿血清E-FABP含量与糖脂代谢、内皮损伤及炎症反应指标均直接相关。结论:代谢综合征患儿血清E-FABP含量异常增高,与机体糖脂代谢、内皮损伤及炎症反应异常程度直接相关。

Objective:To study the correlation of serum E-FABP content with glucose lipid metabolism,endothelial injury and inflammatory response in children with metabolic syndrome.Methods:49children with metabolic syndrome who were treated in the hospital between January2016and February2017were collected as observation group,and50healthy children who received vaccination in the hospital over the same period were collected as normal control group.Serum levels of E-FABP as well as glucose lipid metabolism,endothelial injury and inflammatory response indexes of two groups of subjects were detected,and the Pearson test was used to evaluate the correlation of E-FABP content with glucose lipid metabolism,endothelial injury and inflammatory response.Results:Serum E-FABP content of observation group was higher than that of control group;glucose metabolism indexes FBG and HOMA-IR levels in peripheral blood were higher than those of normal control group;lipid metabolism indexes TC,LDL-C and ApB contents in peripheral blood of observation group were higher than those of normal control group while HDL-C and ApA1contents were lower than those of normal control group;endothelial injury index ET-1content in serum was higher than that of normal control group while NO content was lower than that of normal control group;inflammatory response indexes CRP,IL-1β,IL-6and IL-17contents in serum were higher than those of normal control group(P<0.05).Pearson test showed that serum E-FABP content in children with metabolic syndrome was directly correlated with glucose lipid metabolism,endothelial injury and inflammatory response indexes.Conclusion:Serum E-FABP content increases abnormally in children with metabolic syndrome and is directly correlated with the abnormal degree of glucose lipid metabolism,endothelial injury and inflammatory response.