胃癌根治术后患者生存质量及影响因素分析

Analysis of quality of life and its influencing factors in patients with gastric cancer after radical operation

目的探讨胃癌根治术后患者生存质量及影响因素分析。方法选取2013年1月—2015年12月新疆维吾尔自治区人民医院收治的胃癌确诊患者68例,诊断均符合WHO最新胃癌分类及诊断标准。采用欧洲癌症研究与治疗组织设计的患者生活质量调查问卷(quality of life questionnaire of stomach 22,QLQ-STO22)对患者术前1d及术后1周,术后6个月的生存质量进行评估。于患者术前1d,术后6个月进行调查,回收问卷。对胃癌患者手术前后生存质量的危险因素条件Logistic回归分析。结果胃癌患者术后1周总体生存质量评分及各维度评分中的疼痛、反流症状、进食受限、焦虑评分均高于手术前,经比较差异有统计学意义。术后1个月时,各项指标明显优于术后1周,生存质量总分明显优于1周及术前。术后1个月时疼痛、反流症状、进食受限和焦虑维度得分明显优于术后1周,其中反流症状和焦虑维度得分明显优于手术前,经比较差异有统计学意义(P<0.05)。术后1个月时进食受限维度得分与术前比较差异无统计学意义(P>0.05)。胃癌患者手术前后生存质量的危险因素条件Logistic回归分析结果显示,社会支持、男性是影响生存质量主要因素。结论手术可影响胃癌化疗患者的生活质量,其中社会支持、男性是影响生存质量的主要因素。

Objective To investigate the quality of life and its influencing factors in patients with gastriccancer after radical operation.Methods A total of68patients with gastric cancer treated during Jan.2014and Dec.2015were enrolled.Quality of Life Questionnaire of Stomach22(QLQ-STO22)was used to evaluate the patients'quality of life before surgery,1week and6months after operation.Conditional logistic regression was used to analyze the risk factors of quality of life.Results One week after operation,the overall quality of life score and scores of pain,reflux,eating restriction and anxiety score were significantly improved compared with those before operation(P<0.05),and further improved1month after surgery(P<0.05),except for eating restriction(P>0.05).Social support and male gender were the main factors influencing the quality of life.Conclusion Surgery can affect the quality of life of patients with gastric cancer.Social support and male gender are main influencing factors of quality of life.