吉非替尼在老年晚期肺癌患者中的疗效观察及对存活质量的影响研究

Effect of Gefitinib on Survival Treatment for Patients with Advanced Lung Cancer

目的探讨分析吉非替尼在老年晚期肺癌患者中的疗效及对患者生存期的影响。方法选取2012年3月~2016年4月期间我院收治的老年晚期肺癌患者80例,依据随机数字表法分为对照组和研究组,对照组采用在紫杉醇联合顺铂化疗,研究组采用吉非替尼治疗,观察两组患者的治疗效果以及对患者生存期的影响。结果治疗完成后,研究组和对照组患者的缓解率分别为52.5%、27.5%,研究组明显高于对照组(P<0.05);治疗过程中,研究组患者恶心呕吐、骨髓抑制、脱发、口腔溃疡等不良反应的发生率明显低于对照组(P<0.05);治疗前两组患者血清癌胚抗原(CEA)水平无显著差异(P>0.05),治疗后研究组明显低于对照组(P<0.05);研究组患者的生存时间、无疾病进展生存期以及2年生存率均明显高于对照组(P<0.05)。结论采用吉非替尼治疗老年晚期肺癌可有效减少不良反应,降低血清CEA水平,控制和缓解病情,延长生存时间,治疗效果更加安全有效,值得推广和应用。

Objective To explore the effect of gefitinib in patients with advanced lung cancer and its effect on patients’survival.Methods80elderly patients with advanced lung cancer patients were selected in our hospital between March2012and April2016.They were divided into control group and study group randomly.The patients in control group were given paclitaxel and cisplatin chemotherapy,while those in study group were treated with gefitinib.The treatment effect and the influence on the survival of patients were compared and observed between the two groups.Results The remission rate of the study group and control group was52.5%and27.5%respectively after the treatment,and it was significantly higher in study group than that in the control group(P<0.05).In the course of treatment,the incidence of nausea,bone marrow suppression,hair loss,oral ulcer and other adverse reactions of patients in the study group was significantly lower than in the control group(P<0.05).There was no significant difference in the level of cancer embryo antigen(CEA)in the serum of patients before treatment in the two groups(P>0.05),and it was significantly lower in study group than in the control group after treatment(P<0.05).During the follow-up,the survival time of,the survival period of the disease-free progress and the2-year survival rate of the patients in the study group were significantly higher than in the control group(P<0.05).Conclusion The gefitinib treatment for elderly advanced lung cancer patients can effectively reduce the adverse reaction in the treatment process,reduce serum CEA level,prolong the survival time,so it is more effective and safer,and worthy of popularization and application.