康艾注射液联合常规化疗对晚期非小细胞肺癌患者免疫功能的影响及其疗效分析

Effects of Combination of Kang'Ai Injection and Conventional Chemotherapy on the Immune Function of Patients with Advanced Non-small Cell Lung Cancer

目的探讨康艾注射液联合常规化疗治疗晚期非小细胞肺癌(NSCLC)的疗效及对抗肿瘤免疫的影响。方法2016年6月~2017年4月69例晚期NSCLC患者,回顾治疗方案并分为常规化疗组37例、康艾注射液组32例。常规化疗组患者接受TP化疗,康艾注射液组患者接受TP化疗联合康艾注射液治疗。对比两组患者的近期疗效及Th1/Th2、Th17/Treg免疫细胞水平差异。结果治疗后,康艾注射液组的治疗总有效率高于常规化疗组(P<0.05);康艾注射液组患者外周血中Th1细胞比例及其细胞因子含量高于常规化疗组,Th2细胞比例及其细胞因子含量低于常规化疗组(P<0.05);康艾注射液组患者外周血中Th17细胞比例及细胞因子IL-17的含量,Treg细胞比例及细胞因子IL-35的含量均低于常规化疗组(P<0.05)。结论晚期NSCLC患者接受康艾注射液联合常规化疗,可提升临床治疗效果并优化Th1/Th2、Th17/Treg抗肿瘤免疫功能。

Objective To study the effect of Kang’ai injection combined with chemotherapy on advanced NSCLC patients and their influence on anti-tumor immune.Methods69patientswith advanced NSCLCwere chosen as research subjects in our hospital from June2016to April2017,all patients were divided into routine chemotherapy group(n=37)and Kang’ai injection group(n=32).Patients in routine chemotherapy group were treated with TP chemotherapy,while patients in Kang’ai injection group were treated with TP chemotherapy combined with Kang’ai injection therapy.The short-term curative effect and the difference of Th1/Th2and Th17/Treg immune were compared between the two groups.Results Total efficiency of patients in Kang’ai injection group after treatment was higher than that in routine chemotherapy group(P<0.05);proportion of Th1cells and cytokines of patients in Kang’ai injection group were higher than those in routine chemotherapy group,proportion of Th2cells and cytokines of patients in Kang’ai injection group were lower than those in routine chemotherapy group(P<0.05);proportion of Th17cells and cytokines IL-17,proportion of Treg cells and cytokines of IL-35of patients in Kang’ai injection group were lower than those in routine chemotherapy group(P<0.05).Conclusion Kang’ai injection combined with conventional chemotherapy for patients with advanced NSCLC can improve the clinical treatment effect and optimize anti-tumor immune function of Th1/Th2,Th17/Treg.