特布他林联合甲强龙对慢性阻塞性肺病患者肺功能、血气分析及炎性因子的影响

Effects of terbutaline combined with methylprednisolone on pulmonary function,blood gas analysis and inflammatory factors in patients with chronic obstructive pulmonary disease

目的:探讨特布他林联合甲强龙治疗对慢性阻塞性肺病(COPD)患者肺功能、血气分析及炎症因子的影响。方法:将收治的100例COPD患者按照抽签法随机分为对照组(n=50)和观察组(n=50),两组均行常规治疗。在此基础上,对照组雾化吸入特布他林,观察组给予特布他林雾化吸入和甲强龙注射液联合治疗。检测并对比治疗前后两组COPD患者肺功能改善情况、血气分析改变情况及炎性因子水平。结果:治疗前,两组肺功能指标比较,差异无统计学意义(P>0.05);治疗后,两组FVC和FEV1水平较组内治疗前均显著升高(P<0.05),且观察组高于治疗后对照组比较,差异有统计学意义(P<0.05)。治疗前,两组血气分析指标比较,差异无统计学意义(P>0.05);治疗后,两组PaO2水平较组内治疗前均显著升高(P<0.05),且观察组高于治疗后对照组比较,差异有统计学意义(P<0.05);治疗后,两组PaCO2水平较组内治疗前均显著降低(P<0.05),且观察组低于治疗后对照组比较,差异有统计学意义(P<0.05)。治疗前,两组炎性因子水平比较,无明显差异(P>0.05);治疗后,两组PCT和TNF-α水平较组内治疗前均显著降低(P<0.05),且观察组低于治疗后对照组比较,差异有统计学意义(P<0.05)。结论:特布他林联合甲强龙治疗COPD的效果好,能显著提高肺功能,稳定血气分析值,降低炎症因子浓度,是潜在的有效治疗方案。

Objective:To investigate the effects of terbutaline combined with methylprednisolone on pulmonary function,blood gas analysis and inflammatory factors in patients with chronic obstructive pulmonary disease(COPD).Methods:A total of100patients with COPD were randomly divided into control group(n=50)and observation group(n=50)according to the lottery method.Both groups were treated with conventional therapy.On this basis,the control group was given inhalation of terbutaline.The observation group was given terbutaline inhalation and combination therapy with methylprednisolone.The changes of lung function,changes of blood gas analysis and inflammatory factors were measured before and after treatment in both groups.Results:There were no significant differences in lung function between the two groups before treatment(P>0.05).After treatment,the levels of FVC and FEV1in both groups were significantly higher than those before treatment(P<0.05),and those of the observation group was higher than those of the control group(P<0.05).Before treatment,there was no significant difference between the two groups(P>0.05).After treatment,PaO2levels in both groups were significantly higher than those before treatment(P<0.05),and those of the observation group was higher than those of the control group(P<0.05).After treatment,PaCO2levels in both groups were significantly lower than those before treatment(P<0.05),and the observation group was lower than the control group after treatment(P<0.05).There were no significant differences in the levels of inflammatory factors between the two groups before treatment(P>0.05).After treatment,the levels of PCT and TNF-αin both groups were significantly lower than those before treatment(P<0.05),and those of the observation group was lower than those of the control group after treatment(P<0.05).Conclusion:The effect of Terbutaline combined with methylprednisolone treatment of COPD is better,which can significantly improve lung function,stable blood gas analysis,reduce the concentration of inflammatory factors,and be a potential effective treatment programs.