急性脑梗死患者侧支循环的脑血管造影评估及其与神经功能损伤程度的相关性

The cerebral angiography of collateral circulation in patients with acute cerebral infarction and its correlation with nerve injury

目的:探讨急性脑梗死患者侧支循环的脑血管造影评估及其与神经功能损伤程度的相关性。方法:选择在本院接受治疗的急性脑梗死患者78例,经脑血管造影后分为有侧枝循环组47例、无侧枝循环组31例。对比两组患者血清中神经损伤标志物、神经营养指标、氧化应激指标含量的差异。结果:无侧枝循环组血清中神经损伤标志物Copeptin、H-FABP、S100B、MBP的含量均显著高于有侧枝循环组(P<0.05);血清中神经营养指标BDNF及NGF的含量均显著低于有侧枝循环组(P<0.05);血清中氧化应激指标8-OHdG、LHP的含量高于有侧枝循环组(P<0.05),SOD、CAT的含量低于有侧枝循环组(P<0.05)。结论:脑血管造影可准确评估急性脑梗死患者侧支循环存在与否,无侧支循环者脑损伤更为严重。

Objective:To assess the cerebral angiography of collateral circulation in patients with acute cerebral infarction and investigate its correlation with nerve injury.Methods:78patients with acute cerebral infarction who were treated in the hospital between January2015and June2017were divided into collateral circulation group(n=47)and no collateral circulation group(n=31)after cerebral angiography.The differences in serum levels of nerve injury markers,neurotrophy indexes and oxidative stress indexes were compared between the two groups.Results:Serum nerve injury markers Copeptin,H-FABP,S100B and MBP levels of no collateral circulation group were significantly higher than those of collateral circulation group;serum neurotrophy indexes BDNF and NGF levels were significantly lower than those of collateral circulation group;serum oxidative stress indexes8-OHdG and LHP levels were higher than those of collateral circulation group whereas SOD and CAT levels were lower than those of collateral circulation group.Conclusion:Cerebral angiography can accurately assess the existence of collateral circulation in patients with acute cerebral infarction,and the cerebral injury is more serious in those without collateral circulation.