新型腔肠素衍生物的合成

Synthesis of Novel Coelenterazine Derivatives

以2-氨基吡嗪为原料,经5步反应(两次NBS溴代反应,两次Suzuki交叉偶联反应和HCl作用下的缩合反应),合成了6个新型的C^8-位芳杂环取代的腔肠素衍生物,其结构经~1H NMR和^(13)C NMR表征。

Six C8-heterocyclic substituted coelenterazine derivatives were synthesized by a five-step synthetic route(two NBS bromination,two Suzuki cross coupling reaction and HCl catalyzed condensation)from2-aminopyrazine.The structures were characterized by1H NMR and13C NMR.