慢性阻塞性肺疾病患者抑郁评分与hs-CRP、NT-ProBNP、D-dimer的相关性研究

Correlation between Depression Score and hs-CRP,NT-ProBNP,D-dimer in Patients with Chronic Obstructive Pulmonary Disease

目的观察慢性阻塞性肺疾病患者抑郁自评量表(SDS)评分与超敏C反应蛋白(hs-CRP)、N端前脑钠肽(NT-Pro BNP)、D二聚体(D-dimer)的相关性。方法 50例慢性阻塞性肺疾病合并抑郁患者作为观察组,50例慢性阻塞性肺疾病患者作为对照组,hs-CRP采用免疫比浊法测定,NT-Pro BNP、D-dimer均采用电化学发光免疫法定量测定,比较两组hs-CRP、NT-Pro BNP、D-dimer表达水平,观察组SDS评分与hs-CRP、NT-Pro BNP、D-dimer的关系。结果两组血清hs-CRP、NT-Pro BNP、D-dimer表达水平差异无统计学意义(P>0.05),观察组SDS:轻度抑郁17例(56~62分),中度抑郁15例(63~72分),重度抑郁18例(>72分),hs-CRP、NT-Pro BNP、D-dimer表达差异无统计学意义(P>0.05)。结论慢性阻塞性肺疾病患者hs-CRP、NT-Pro BNP、D-dimer表达,与其抑郁症的发生无明显相关性。

ObjectiveTo explore correlation between depression score(self rating depression scale,SDS)and high sensitivity C reactive protein(hs CRP),N terminal pro brain natriuretic peptide(NT ProBNP),D dimer in patients with chronic obstructive pulmonary disease(COPD).Methods50cases of COPD combined with depression were selected as observation group,and50patients with COPD as control group.hs CRP was measured by turbidimetric immunoassay,NT ProBNP and D dimer were determined by electrochemiluminescence immunoassay.The expression levels of hs CRP,NT ProBNP and D dimer were compared between the two groups.The relationship between SDS score and hs CRP,NT ProBNP and D dimer was observed.ResultsThe serum levels of hs CRP,NT ProBNP and D dimer were not significantly different between the two groups(P>0.05),the observation group was evaluated by SDS:mild17cases(56~62points),moderate15cases(63~72points),severe18cases(>72points),the levels of serum hs CRP,NT ProBNP and D dimer were not statistically significant in COPD with depression(P>0.05).ConclusionThe expression of hs CRP,NT ProBNP and D dimer in patients with COPD was not significantly correlated with the occurrence of depression.