摘要
特发性脊柱侧凸(idiopathic scoliosis,IS)是一种病因尚不明确的脊柱三维畸形,也是脊柱侧凸中最常见的一种。IS好发于青少年,并且有进展的可能,严重影响儿童及青少年的身心健康。近年来,IS的基因学研究越来越受到关注。现就IS的遗传模式、相关候选基因、候选基因表达的研究进展予以综述,旨对IS的早期诊断和精准干预起积极的作用。
Idiopathic scoliosis(IS)is a three dimensional deformity of the spine.IS is the most common type of scoliosis but its pathogenesis has not been clearly defined.IS occurs mainly in adolescents and has the potential for further progression,affecting physical and mental health of children and adolescents.In recent years,IS genetic research has generated considerable attention.In order to promote early diagnosis and accurate intervention of IS and spine health in children and adolescents,this paper reviews researches of IS genetic model,candidate genes,and candidate gene expression.
作者
牛瑶
周璇
杜青
NIU Yao;ZHOU Xuan;DU Qing(Department of Rehabilitation Medicine, Xinhua Hospital (Chongming), Shanghai Jiao Tong University School of Medicine, Shanghai 202150, China;School of Sport Science, Shanghai University of Sport, Shanghai 200438, China;Department of Rehabilitation Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China)
出处
《教育生物学杂志》
2017年第4期210-215,共6页
Journal of Bio-education
基金
上海市卫生计生系统重要薄弱学科建设计划(2015ZB0406)
上海交通大学医学院附属新华医院崇明分院科研基金项目(YL201701)
新华医院院级临床研究培育基金项目(17CSK02)
