低分子肝素治疗复发性流产孕妇血栓前状态的疗效研究

The curative effect of low molecular heparin treating pregnant women with recurrent miscarriage and prethrombotic state

目的探讨低分子肝素对血栓前状态(PTS)并有复发性流产史孕妇的凝血功能及妊娠结局的影响。方法收集我院2016年8月—2017年1月有复发性流产史并处于血栓前状态的孕妇27例为实验组,给予低分子肝素治疗,收集既往使用阿司匹林治疗的有复发性流产史并处于血栓前状态的孕妇29例为对照组,比较两组患者的凝血功能相关指标、妊娠结局和妊娠并发症发生情况的差异。结果治疗后实验组患者凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白(FIB)明显低于对照组,活产率明显高于对照组,差异有统计学意义(P<0.05);两组患者凝血酶时间(TT)、妊娠并发症发生率差异无统计学意义(P>0.05)。结论低分子肝素能有效纠正复发性流产孕妇的凝血功能,改善血栓前状态,提高活产率。

Objective:To explore the impact of coagulation function and pregnancy outcomes using low molecular heparin in pregnant women with recurrent miscarriage and prethrombotic state.Methods:Twenty seven pregnant women with recurrent miscarriage and prethrombotic state were collected from August2016to January2017as the experimental group,and treated by low molecular heparin.Twenty nine previous cases were collected and treated by aspirin as control group.The difference in coagulation function,pregnancy outcomes and pregnancy complications were compared between two groups.Results:Prothrombin time(PT),activated partial thromboplastin time(APTT),fibrin(FIB)of experimental group were lower than those in the control group's,and the difference was statistically significant(P<0.05).The difference of thrombin time(TT)and the incidence of pregnancy complications was not statistically significant(P>0.05).Conclusion:Low molecular heparin can effectively correct the coagulation function,prethrombotic state and improve the live birth rates of pregnant women.