丹参川芎嗪注射液联合辛伐他汀对慢性肺源性心脏病右心功能的影响

Effect of Danshen Ligustrazine Injection Combined with Simvastatin on Right Ventricular Function of Chronic Pulmonary Heart Disease

目的观察丹参川芎嗪注射液联合辛伐他汀对慢性肺源性心脏病(CPHD)右心功能的影响。方法选择2015年1月—2017年5月收治的120例CPHD,按治疗方法分为观察组和对照组,每组60例。两组均给予常规治疗,对照组在常规治疗基础上给予丹参川芎嗪注射液治疗,观察组在对照组基础上给予辛伐他汀治疗。观察治疗前后两组6 min步行距离、血气分析变化情况以及超声心动图检查指标,并观察两组不良反应发生情况。结果与治疗前比较,两组治疗后6 min步行距离增加,右心室射血分数、动脉血氧饱和度和氧分压明显升高,肺动脉收缩压及舒张末期右心室横径减小,二氧化碳分压降低(P<0.05)。治疗后,观察组6 min步行距离长于对照组,肺动脉收缩压及舒张末期右心室横径小于对照组(P<0.05)。两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论丹参川芎嗪注射液联合辛伐他汀可有效改善CPHD患者心功能,改善缺氧症状,且安全性高。

Objective To observe effect of Danshen Ligustrazine injection combined with Simvastatin on right ventricular function of patients with chronic pulmonary heart disease(CPHD).Methods A total of120CPHD patients admitted during January2015and May2017were divided into observation group(n=60)and control group(n=60).All patients had received conventional treatments.Control group was treated with Danshen Ligustrazine injection on the basis of conventional treatment,while observation group was treated with Simvastatin on the basis of treatment for control group.Changes of6min walking distance and blood gas analysis before and echocardiography indexes were observed before and after treatment,and incidence rate of adverse reactions were also observed in two groups.Results Compared with those before treatment,values of6min walking distance,right ventricular ejection fraction,arterial oxygen saturation and oxygen partial pressure were significantly increased,while values of pulmonary arterial systolic pressure,the end diastolic trans diameter of right ventricle and partial pressure of carbon dioxide were significantly decreased after treatment in two groups(P<0.05).After treatment,in observation group,values of walking distance of6min were significantly longer,pulmonary arterial systolic pressure and end diastolic trans diameter of right ventricle were significantly lower than those in control group(P<0.05).There was no significant difference in the total incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Danshen Ligustrazine injection combined with Simvastatin may effectively improve heart function and symptoms of hypoxia with high safety in treatment of patients with chronic pulmonary heart disease.