丹红注射液不良反应的表现、影响因素及预防方法分析

The Performance of Adverse Reactions of Danhong Injection and Analysis of the Influencing Factors and Prevention Methods

目的:探讨丹红注射液不良反应的表现、影响因素及预防方法。方法:纳入2014年3月至2016年3月我院采用丹红注射液治疗2 789例患者作为本次研究对象,对其临床资料进行回顾性分析与总结,以评价丹红注射液临床应用安全性。结果:药物所致患者不良反应发生情况:2 789例患者中,出现不良反应/事件62例,确定不良反应/事件发生例数53例,不良反应发生率为1.90%。不良反应与药物应用剂量关系:药物应用剂量不同,患者间不良反应发生率有显著性差异P<0.05。不良反应与患者性别关系:女性、男性患者间不良反应发生率有显著性差异P<0.05。不良反应与患者年龄关系:不同年龄段患者间不良反应发生率有显著性差异P<0.05。不良反应与患者病种关系:不同病种患者间不良反应发生率无明显差异P>0.05。53例患者不良反应发生情况:循环系统不良反应发生率为34.0%;神经系统不良反应发生率为30.2%;皮肤部位不良反应发生率为26.3%;消化系统不良反应发生率为5.7%;其他方面不良反应发生率为3.8%。不良反应症状处理情况:53例患者经调整滴速、对症处理后,不良反应症状均消失,未见严重不良反应病例出现。结论:丹红注射液引发患者出现不良反应因素较多,通过有效预防性措施的实施,可减少或避免药物所致不良反应发生,对确保用药安全及提高治疗效果具有重要作用。

Objective:To investigate the performance of Danhong injection adverse reaction,influence factors and prevention.Methods:2789patients from March2014to March2016treated in our hospital with Danhong injection as the research object,the clinical data were retrospectively analyzed and summarized,in order to evaluate the clinical application safety of Danhong injection.Results:The incidence of adverse drug reactions:2789cases of patients,62cases of adverse reaction/event,53cases determined adverse reaction/incident,the incidence of adverse reaction was1.90%.Adverse reaction and application dose relationship:application of different doses of drugs,the adverse reaction rate had significant difference,P<0.05.Adverse reactions and patients gender:the incidence of adverse reactions of female,male patients were significantly different,P<0.05.Adverse reaction and the age of patients:the incidence of adverse reactions of different age patients were significantly different,P<0.05.Adverse reactions and disease relationship:the incidence of adverse reaction of patients with different diseases had no significant difference,P>0.05.In53cases of adverse events,the incidence of adverse reactions of the circulatory system was34.0%,the incidence of neurological adverse reactions was30.2%,the incidence of skin adverse reactions was26.3%,the incidence of digestive system adverse reactions was5.7%,the incidence of other adverse reaction was3.8%.Adverse reaction symptom treatment:53patients after adjustment of the dropping speed or symptomatic treatment,symptoms of adverse reactions disappeared,there were no serious adverse reactions cases.Conclusion:There are many factors causing adverse reactions of Danhong injection,through the implementation of effective preventive measures,can reduce or avoid the occurrence of drug-induced adverse reactions,which plays an important role to ensure drug safety and improve the therapeutic effect.