肝硬化对乙肝相关性肝癌根治术预后的影响

Relationship between liver cirrhosis and prognosis of HBV-related hepatocellular carcinoma

目的分析肝硬化与乙肝相关性肝癌预后的关系。方法回顾性分析2005~2012年收治的166例乙肝相关肝癌患者,所有患者已行肝切除术。男性134例,女性32例;年龄32~73岁;其中无肝硬化25例;小结节肝硬化(肝硬化结节≤3 mm)61例;大结节肝硬化(肝硬化结节>3 mm)80例。比较3组患者肝切除术后复发率及总生存率。结果无肝硬化、肝硬化小结节及肝硬化大结节组患者术后复发率及总生存率比较,差异有统计学意义(P<0.05),无肝硬化组患者术后复发率及总生存率优于肝硬化小结节及大结节组患者。肝硬化小结节组和肝硬化大结节组患者术后复发率及总生存率比较,差异无统计学意义(P>0.05)。结论乙肝相关性肝癌患者中,无肝硬化肝癌患者肝切除术后复发率及总生存率优于肝硬化的肝癌患者。

Objective To investigate the relationship between liver cirrhosis and prognosis of HBV-related hepatocellular carcinoma(HCC).Methods The clinical data of166patients with HBV-related HCC from2005to2012were retrospectively reviewed.All patients received liver resection for the treatment of HCC.Among them,134were male and32were female.The patients’age was within a range of32-73years at the time of diagnosis.Of the166patients,25did not have liver cirrhosis,61had liver cirrhosis with small nodules(≤3mm),80had liver cirrhosis with big nodules(>3mm).The recurrence rate(RR)and overall survival(OS)were analyzed and compared among the three groups.Results There were significant differences in RR and OS among the three groups(P<0.05),and the HCC patients without liver cirrhosis had better RR and OS than the HCC patients with liver cirrhosis,while the differences of RR and OS were not significant between the HCC patients with small-nodule liver cirrhosis and those with big-nodule liver cirrhosis(P>0.05).Conclusions HCC patients without liver cirrhosis have better RR and OS than those with liver cirrhosis.