4-(E-3-乙氧基-3-氧代-1-丙烯-1-基)苯基硼酸的合成工艺研究

Synthesis of(E)-(4-(3-ethoxy-3-oxoprop-1-en-1-yl)phenyl)boronic acid

4-(E-3-乙氧基-3-氧代-1-丙烯-1-基)苯基硼酸是一种重要的有机中间体。本文以4-甲酰基苯硼酸为起始原料,经Wittig-Horner反应合成了标题化合物。该合成方法未见文献报道,原料廉价易得,操作简便易控,反应条件温和,产品纯度较高,适合工业化生产。反应收率为78.8%。

In this paper,a new synthetic route for(￡)"4-(3-ethoxy-3-oxoprop-1-en-1-yl)phenyl)boronic acid was designed.4-formylphenylboronic acid was used as the starting material to synthesize the target product by Wittig-Horner reaction.The route had the advantages of low cost,easy to obtain raw materials,easy to operate,mail reaction conditions,simple post-processing,suitable for industrial,the total yield of78.8%.