探讨不同分期主动脉夹层患者凝血功能的变化

To explore the changes of coagulation function in patients with different stages of aortic dissection

目的探讨不同分期和不同年龄区间主动脉夹层患者凝血功能的变化。方法2015年11月至2017年2月我院收治主动脉夹层患者95例,选年龄相匹配的健康对照组55例,用Sysmex CS5100检测入选人群的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB),并进行统计学分析。结果主动脉夹层组PT、APTT和FIB均明显高于对照组,且具有统计学意义(P<0.05),但与对照组相比急性期患者FIB浓度没有显著变化(P>0.05);与急性期主动脉夹层患者相比亚急性及慢性期患者PT、APTT和FIB明显高于前者,且均有统计学差异(P<0.01)。结论主动脉夹层可引起机体凝血和纤溶系统产生一系列变化,最终破坏二者的平衡致使机体呈现高凝状态,产生严重的并发症或(和)死亡。

Objective To explore the changes of coagulation function in patients with different stages of aortic dissection.Methods From November2016to February2016,95patients with aortic dissection were treated in our hospital,choosed Age-matched healthy adult group55cases,Sysmex CS5100was used to detect the PT,APTT and FIB in the selected population,and the results were analyzed statistically.Results The levels of PT,APTT and FIB in the aortic dissection group were significantly higher than those in the control group(P<0.05),but the concentration of FIB compared with the control group there was no significant change in the acute phase(P>0.05).The levels of PT,APTT and FIB in patients with acute and chronic phase were significantly higher than those in the patients with acute aortic dissection(P<0.01).Conclusion Aortic dissection could cause the body produce a series of changes,such as coagulation and fibrinolysis system,and ultimately destroied the balance of the two causes,then the body may show hypercoagulable state,resulting in serious complications or(and)death.