系统性红斑狼疮患者活动性发热特点及相关性分析

The Characteristics and Correlation Analysis of Active Fever in Patients With Systemic Lupus Erythematosus

目的分析系统性红斑狼疮患者活动性发热特点及相关性。方法选取本院64例系统性红斑狼疮患者作为研究对象,根据有无出现活动性发热,将其分为发热组与非发热组,每组各32例。对比分析两组患者的临床表现、实验室指标、免疫学指标及用药情况,多因素分析各指标与活动性发热的相关性。结果活动性发热患者常表现为浆膜炎、神经系统受累、肝脾淋巴结肿大,且实验室指标、免疫学指标的异常率较高;Logistic回归分析结果显示,活动性发热与白细胞异常、C反应蛋白异常、丙氨酸转氨酶异常呈正相关,与入院年龄、血红蛋白异常异常、血清肌酐异常、环磷酰胺使用率呈负相关。结论系统性红斑狼疮患者活动性发热特点较为明显,分析其影响因素,有助于该病的防治。

Objective To analyze the characteristics and correlation of active fever in patients with systemic lupus erythematosus(SLE).Methods64cases of patients with systemic lupus erythematosus,according to the presence of active heating,they were divided into the fever group and nonfever group,32cases in each group,comparative analysis of two groups of patients with clinical manifestations,laboratory indexes,immunological indexes and medication,multivariate correlation analysis of each index and activity of fever.Results Patients with febrile Changbiaoxianwei serositis,nervous system involvement,lymphadenectasis,and laboratory indexes,immunological indexes abnormal rate;Logistic regression analysis showed that the activity of fever and abnormal white blood cells,C reactive protein,abnormal alanine aminotransferase abnormalities were positively correlated with age,hemoglobin abnormal,abnormal serum creatinine,cyclophosphamide use rate was negatively correlated.Conclusion The characteristics of active fever in patients with systemic lupus erythematosus are more obvious,and the analysis of the influencing factors is helpful to the prevention and treatment of the disease.