贝那普利、氨氯地平对中老年高血压患者血压变异性的影响

The Effect of Benazepril and Amlodipine on Blood Pressure Variability in Middle-aged and Elderly Hypertensive Patients

目的分析贝那普利与氨氯地平对中老年高血压患者血压变异性的影响。方法选取我所中老年高血压患者86例随机将其分为单一组(43例)单纯使用贝那普利进行治疗,联合组(43例)行贝那普利与氨氯地平联合治疗,对比两组患者临疗效与血压变异性(白天舒张血压变异性(d DBPV)、白天收缩血压变异性(d SBPV)、夜晚舒张血压变异性(nDBPV)、夜晚收缩血压变异性(n SBPV)、24 h平均舒张血压变异系数(24 h DBPV)、24 h平均收缩血压变异系数(24h SBPV)情况。结果联合组疗效优于单一组,组间对比,差异具有统计学意义(P<0.05);治疗后联合组血压变异性各项指标均低于单一组,组间对比,差异具有统计学意义(P<0.05)。结论贝那普利、氨氯地平有助于中老年高血压患者血压的控制,降低患者血压变异性。

Objective To analyze the effect of benazepril and amlodipine on blood pressure variability in middle-aged and elderly hypertensive patients.Methods A total of86middle-aged and elderly patients with hypertension were randomly divided into a single group(43cases)treated with benazepril alone and a combined group(43cases)treated with benazepril combined with amlodipine.Compared two groups of patients with clinicalcurative effect and blood pressure variability(daytime diastolic blood pressure variability(d DBPV),daytime systolic blood pressure variability(dSBPV),night diastolic blood pressure variability(n DBPV),night systolic blood pressure variability(n SBPV),24h mean diastolic blood pressure variability(24h DBPV),24h mean systolic blood pressure variability(24h SBPV).Results The curative effect of the combined group was better than that of the single group,and the difference between the groups was statistically significant(P<0.05).After treatment,the blood pressure variability index of the combined group was lower than that of the single group,and the difference between the groups was statistically significant(P<0.05).Conclusion Benazepril and amlodipine can be used to control the blood pressure in middle-aged and elderly hypertensive patients and reduce the variability of blood pressure in patients with hypertension.