紫河车联合寿胎丸加味治疗冷冻胚胎移植术后雌激素低下先兆流产患者临床研究

Clinical study of estrogen deficiency in patients with threatened abortion after transplantation treated by placenta combined with Shoutai pill on the frozen embryos

[目的]以冷冻胚胎移植(FET)术后雌二醇(E2)低的先兆流产患者为对象,采用紫河车联合寿胎丸加味治疗,观察临床疗效。[方法]选择FET术后14 d,100<E2<200 pg/m L的先兆流产患者160例,随机分配至治疗组和对照组。观察治疗前后中医症状评分,E_2、血清绒毛膜促性腺激素(β-HCG)上升情况及妊娠成功率。[结果]两组患者治疗后中医临床症状积分较治疗前显著下降(P<0.01);血清E2、β-HCG水平均显著高于本组治疗前水平(P<0.01)。与对照组相比,治疗组治疗后所有症状积分显著下降(P<0.05);E2、β-HCG水平显著升高(P<0.05)。治疗组和对照组妊娠成功率分别为77.5%、62.5%,差异有统计学意义(P<0.05)。[结论]紫河车联合寿胎丸加味中药可有效改善FET术后雌激素低下先兆流产中医临床症状,显著提升雌激素及β-HCG水平,提高妊娠成功率,值得临床中推广使用。

[Objective]At low E2after FET in patients with threatened abortion as the object,the placenta combined with Shoutai pill therapy,clinical observation.[Methods]The160cases of threatened abortion with100<E2<200pg/mL14days after FET were randomly assigned to the treatment group and the control group.The TCM symptom score,E2,β-HCG increase and pregnancy success rate were observed before and after treatment.[Results]The clinical symptom scores of the two groups were significantly lower than those before treatment(P<0.01),and the serum levels of E2andβ-HCG were significantly higher than those in the group before treatment(P<0.01).Compared with the control group,the scores of all symptoms in the treatment group decreased significantly(P<0.05),and the levels of E2andβ-HCG increased significantly(P<0.05).The successful rate of pregnancy in the treatment group and the control group were77.5%and62.5%,respectively,and the difference was statistically significant(P<0.05).[Conclusion]Placenta combined with Shoutai pill of Chinese medicine can effectively improve the frozen embryo transplantation of low estrogen symptoms of threatened abortion,significantly increased estrogen andβ-HCG level,improve the success rate of pregnancy,which is worthy to be popularized in clinical.