乌司他丁联合连续性血液净化治疗重症脓毒症的临床效果

Clinical effect of ulinastatin combined with continuous blood purification on severe sepsis

目的探讨乌司他丁联合连续性血液净化治疗重症脓毒症的临床效果。方法将我院急诊科2016年1月至2017年5月收治的76例重症脓毒症患者作为研究对象,根据治疗方法分为两组,各38例。血液净化组采用连续性血液净化治疗,血液净化+药物组采用乌司他丁联合连续性血液净化治疗。比较两组患者的治疗效果。结果血液净化+药物组患者的治疗总有效率为94.73%,显著高于血液净化组的76.32%(P<0.05)。干预后,血液净化+药物组的CRP、白细胞数量优于血液净化组,症状消失时间、住院时间均短于血液净化组(P<0.05)。结论乌司他丁联合连续性血液净化对重症脓毒症的治疗效果确切,可有效改善患者的血清学各指标水平,加速症状消退,缩短住院时间,改善患者预后。

Objective To investigate the therapeutic effect of ulinastatin combined with continuous blood purification on severe sepsis.Methods Seventy-six patients with severe sepsis admitted in the emergency department of our hospital from January2016to May2017were selected and divided into two groups according to the treatment methods,with38cases in each group.Blood purification group was treated with continuous blood purification treatment,blood purification+drug group was treated with ulinastatin combined with continuous blood purification treatment.The clinical effects between the two groups were compared.Results The total effective rate of the blood purification+drug group was94.73%,which was higher than76.32%of the blood purification group(P<0.05).After treatment,CRP and white blood cell count in the blood purification+drug group were better than those in the blood purification group,the symptom disappearance time and hospital stays were shorter than those in the blood purification group(P<0.05).Conclusion Ulinastatin combined with continuous blood purification is effective in the treatment of severe sepsis,which can effectively improve the serum index,accelerate the symptoms subsided,shorten the hospitalization time and improve the prognosis of the patients.