头孢他啶和头孢哌酮/舒巴坦治疗脑卒中合并肺部感染的效果观察

The Effect of Ceftazidime and Cefoperazone/Sulbactam in the Treatment of Cerebral Apoplexy with Pulmonary Infection

目的:观察和分析头孢他啶和头孢哌酮/舒巴坦治疗脑卒中合并肺部感染的效果。方法:选择本院于2014年11月—2017年1月间收治的184例脑卒中合并肺部感染患者为研究主体。划分为A组和B组,分别是93例和91例。A组给予头孢哌酮/舒巴坦治疗,B组给予头孢他啶治疗。对比治疗一个月后的整体疗效、细菌清除率、不良反应情况以及意识障碍情况。结果:A组的治疗总有效率是97.85%,B组是86.81%,对比差异显著,有统计学意义(P<0.05)。A组痰培养检出细菌93株,细菌清除率为88.17%;B组痰培养检出细菌91株,细菌清除率为65.93%,对比差异明显,有统计学意义(P<0.05)。A组的不良反应率为3.23%,B组为3.30%,对比无差异,无统计学意义(P>0.05);A组患者总意识障碍率(3.23%)显著低于B组患者总意识障碍率(16.48%),两组数据差异对比具有统计学意义(P<0.05)。结论:与头孢他啶相比,头孢哌酮/舒巴坦治疗脑卒中合并肺部感染的疗效更佳,可以有效清除感染细菌,且安全性高,值得推广。

Objective:To observe and analyze the effect of ceftazidime and Cefoperazone/sulbactam in the treatment of cerebral stroke complicated with pulmonary infection.Methods:184cases of cerebral apoplexy with pulmonary infection in our hospital in November2014-January2017were selected as the main body of the study.It was divided into group A and group B,which were93cases and91cases respectively.Group A was treated with Cefoperazone/sulbactam,and group B was treated with ceftazidime.The overall curative effect,the adverse reaction of bacterial clearance and the disturbance of consciousness after one month were compared.Results:The total effective rate of treatment in group A was97.85%,and that in group B was86.81%,and the difference was significant(P<0.05).In group A,93strains of bacteria were detected in sputum culture,and the clearance rate of bacteria was88.17%.In group B,91strains of bacteria were detected in sputum culture,and the clearance rate of bacteria was65.93%,the difference between them was statistically significant(P<0.05).The adverse reaction rate of group A was3.23%,B was3.30%(P>0.05);A group of patients with the total rate of disturbance of consciousness(3.23%)was significantly lower than that of B group(16.48%)(P<0.05).Conclusion:Compared with ceftazidime,Cefoperazone/sulbactam is effective in treating stroke complicated with pulmonary infection.It can effectively remove infection bacteria and has high safety and is worth promoting.