不同剂量复方米非司酮联合米索前列醇终止8～16周妊娠的临床研究

Clinical Study on the Termination of 8～16 Week Pregnancy with Mifepristone Combined with Misoprostol at Different Doses

目的:研究不同剂量复方米非司酮联合米索前列醇终止8~16周妊娠的临床效果。方法:以自愿要求终止妊娠的8~16周妊娠妇女72例为研究对象,使用随机双盲法将其分为2组(观察组36例、对照组36例)并分别接受不同剂量的复方米非司酮+米索前列醇治疗,对比其流产相关指标差异。结果:观察组患者流产成功率(94.4%)与对照组患者(80.6%)相比有明显上升,对比存在统计学意义(P<0.05)。观察组患者在米索前列醇用量及流产所用时间上均低于对照组,对比存在统计学意义(P<0.05)。同时,两组患者治疗周期内均未见明显不良反应出现,检查结果显示一切正常。结论:复方米非司酮联合米索前列醇对终止8~16周妊娠患者有着显著效果,安全性高,同时患者复方米非司酮用药量越高则其流产所用时间及米索前列醇所用剂量越小,值得推广。

Objective:To study the clinical effect of different doses of mifepristone combined with misoprostol for the termination of8~16week pregnancy.Methods:72cases of voluntary termination of pregnancy8~16weeks pregnant women were chosen as the research object,and randomly divided into2groups(36cases in the observation group,36cases in the control group),and were treated with different doses of compound mifepristone and misoprostol treatment.The abortion related index differences were compared.Results:The rate of abortion success(94.4%)in the observation group was significantly higher than that in the control group(80.6%),(P<0.05).The patients in the observation group were lower than the control group in the dosage of misoprostol and the time of abortion(P<0.05).At the same time,there was no obvious adverse reaction in the two groups of patients during the treatment period,and the results showed that all of them were normal.Conclusion:Compound mifepristone combined with misoprostol is effective and safe for terminating8~16weeks of pregnancy.Meanwhile,the higher the dosage of mifepristone is,the less time it takes for abortion and the dosage of misoprostol,which is worth promoting.