蛋白质和多肽药物稳定性研究进展

Research Progress in Drug Stability of Proteins and Polypeptides

目前,蛋白质和多肽类药物在临床中被广泛应用。与小分子药物相比,蛋白质和多肽类药物具有良好的生物活性,高度专一性以及低毒性,但是其稳定性低,且易被清除,这限制了其药效的最大发挥。本文分析了不同给药方式下影响蛋白质及多肽类药物药效的主要因素,并对提高药物稳定性的方法进行了简介。

At present,protein and polypeptide drugs are widely used in clinic.Compared with small molecule drugs,protein and polypeptide drugs have good biological activity,high specificity and low toxicity,but their stability is low and easy to be eliminated,which limits the maximum play of their efficacy.In this paper,the main factors affecting the drug efficacy of proteins and polypeptides under different administration modes were analyzed,and the methods to improve drug stability were introduced.