健脾祛湿化痰汤辨证施治脾虚痰湿证糖尿病前期的疗效研究

Clinical efficacy of the Jianpi Qushi Huatan decoction on pre-diabetes with the Pixu Tanshi symptom

目的:观察健脾祛湿化痰汤辨证施治脾虚痰湿证糖尿病前期的临床疗效。方法:将符合标准的100例研究对象随机分为中药组和对照组,各50例。对照组给予包括控制饮食、适量运动等在内的生活干预,中药组在对照组的基础上给予健脾祛湿化痰汤治疗。两组均治疗3个月。观察两组患者治疗前后血糖(FPG、2h PBG和Hb A1c)、血脂水平(TC、TG和LDL)变化的情况及患者用药后的不良反应。结果:两组患者治疗后FPG、2h PBG和Hb A1c水平及TC、TG及LDL水平均有所下降,差异均有统计学意义(P<0.05,P<0.01);治疗后,中药组FPG、2h PBG和Hb A1c水平及TC、TG及LDL水平均较对照组低,差异均有显著统计学意义(P<0.01)。两组治疗过程中均未出现明显不良反应。结论:健脾祛湿化痰汤能有效降低脾虚痰湿证糖尿病前期患者的血糖、血脂水平,而且安全性高,值得临床应用。

Objective:To observe the clinical efficacy of the Jianpi Qushi Huatan decoction on pre-diabetes with Pixu Tanshi symptom.Methods:100cases were randomly divided into the TCM group and the control group,50cases in each.The control group was given diet,moderate exercise and other lifestyle intervention.The TCM group was given the Jianpi Qushi Huatan decoction more.Results:The levels of FPG,2h PBG,HbA1c,TC,TG and LDL in groups were decreased;and the difference was statistically significant(P<0.05,P<0.01).And the levels of FPG,2h PBG,HbA1c,TC,TG and LDL in the TCM group were lower than those in the control group(P<0.01).There was no obvious adverse reaction in two groups.Conclusion:The Jianpi Qushi Huatan decoction can effectively reduce the levels of blood sugar and blood lipids,with higher safety,and is worthy of clinical application.