特发性肺纤维化患者报告结局测评工具文献研究

Patient-reported Outcome Instruments for Idiopathic Pulmonary Fibrosis:a Literature Review

目的分析特发性肺纤维化患者报告结局(IPF-PRO)测评工具的研制及应用现状。方法 2017年4—6月,计算机检索Pub Med、EMBase、中国知网、中国生物医学文献数据库、万方数据知识服务平台和维普网关于IPF临床疗效测评工具的研制、应用的文献,提取第一作者、题目、发表时间、涉及的测评工具及其领域等信息。结果本研究共纳入文献65篇,其中英文文献27篇,中文文献38篇;IPF-PRO测评工具研究文献最早见于2000年,而国内最早见于2007年;关于测评工具研制、信度考核、效度考核、适用性评价的文献有20篇,研究各种治疗措施对IPF患者生存质量影响的文献45篇;涉及IPF-PRO测评工具共23个。测评工具的领域主要包括症状、日常活动能力、心理情绪、社会活动、经济状况、疗效满意等内容。中文、英文文献均对圣·乔治呼吸疾病问卷(SGRQ)的使用频次较多。结论当前临床研究多缺乏基于我国文化背景研制的IPF-PRO测评工具,亟须加强能够反映中医疗效优势的IPF相关特异性测评工具的研制。

Objective To analyze current status of the development and application of patient-reported outcome(PRO)instruments for idiopathic pulmonary fibrosis(IPF)based on a literature review.Methods From April to June,2017,we searched PubMed,EMBase,CNKI,SinoMed,Wanfang Data Knowledge Service Platform and VIP for studies about the development and application of PRO instruments for assessing IPF.We extracted the included studies'data about the first author,title,publication time,and involved PRO instruments for assessing IPF and related fields.Results Totaled 65 articles were eligible,including 27 in English and 38 in Chinese.The PRO instruments for IPF were first reported abroad in 2000,but domestically in 2007.Twenty articles focused on the development,reliability,validity and applicability testing of the scales for IPF and 45 articles focused on assessing the efficacy of various treatments on quality of life of IPF patients.Twenty-three instruments were involved;the instruments were mainly used for assessing the symptoms,daily activity abilities,psychological mood,social activities,economic conditions,and efficacy satisfaction in the IPF patients.SGRQ was used commonly in both English and Chinese articles.Conclusion In these available studies,only a few PRO instruments for IPF were developed in China.PRO instruments for IPF treated by Chinese medicine urgently need to be developed.