五粒回春丸联合阿昔洛韦治疗小儿手足口病的应用研究

A study on treating children with hand foot and mouth disease with Wuli Huichun Wan plus acyclovir

目的:采用五粒回春丸联合阿昔洛韦治疗小儿手足口病的疗效观察,并观察不良反应发生率。方法:选择2015年1月-2016年6月治疗的小儿手足口病患儿,随机分为两组,对照组45例采用阿昔洛韦治疗,10mg·kg-1·d-1,注入0.9%生理盐水或5%葡萄糖100~200m L中进行静脉滴注,1次/d;观察组45例采用五粒回春丸联合阿昔洛韦治疗。两组患者共治疗5d,观察治疗后的体温恢复时间、口腔溃疡愈合时间、皮疹消退时间、住院时间和中医证候改善情况、统计两组患儿的不良反应发生率。结果:观察组体温恢复时间、口腔溃疡愈合时间、皮疹消退时间、住院时间均少于对照组(P<0.05),对比具有统计学意义;对照组中医证候显著改善20例、部分改善15例、无改善10例,观察组显著改善34例、部分改善7例、无改善4例,经检验表明观察组中医证候改善情况优于对照组(P<0.05),对比具有统计学意义;对照组不良反应发生率为8.89%(4/45),观察组不良反应发生率为6.67%(3/45),两组患儿不良反应发生率对比无差异(P>0.05)。结论:经五粒回春丸联合阿昔洛韦治疗小儿手足口病能有效的缩短患儿的病程,中医证候改善较为明显,无明显的不良反应,临床运用的疗效及安全性较高,值得在临床中推广实施。

Objective:To observe the effect of Wuli Huichun Wan(五粒回春丸)plus acyclovir on children with hand foot and mouth disease and its reverse reaction rate.Methods:Children with hand foot and mouth disease treated in our hospital from January2015to June2016were randomly divided into two groups.The control group(45cases)received acyclovir treatment,10mg/(kg·d),intravenous drip in0.9%physiological saline or5%glucose(100~200ml);the observation group(45cases)received Wuli Huichun Wan plus acyclovir.The groups were treated for5days.The recovery time of body temperature,healing time of oral ulcer,rash subsiding time,hospitalization time and improvement of TCM syndromes were observed.The incidence of adverse reactions in two groups was statistically analyzed.Results:The recovery time of body temperature,healing time of oral ulcer,rash subsiding time,and hospitalization time in the observation group was significantly shorter than that in the control group;the difference was statistically significant(P<0.05).In the control group,20cases of TCM syndrome were significantly improved;15cases were partially improved;,10cases were not improved.In the observation group,34cases were significantly improved;7cases were partially improved and4cases were not improved.The test showed that the improvement of TCM syndrome in the observation group was better than that of the control group;the difference was statistically significant(P<0.05);Incidence of adverse reactions in the control group was8.89%(4/45)and6.67%(3/45)in the observation group;the difference was not statistically significant(P>0.05)Conclusion:Wuli Huichun Wan plus acyclovir was effective to shorten the course of children's disease,the improvement of TCM syndrome was more obvious,and there was no obvious adverse reaction in treating children with hand foot and mouth disease.Its efficacy and safety of clinical application were high,and it was worth popularizing in clinical practice.