短效与长效硝苯地平治疗妊娠高血压的临床疗效比较

Comparison of short effect and long effect nifedipine in the treatment of pregnancy induced hypertension

目的比较分析短效与长效硝苯地平治疗妊娠高血压的临床疗效。方法随机抽取2015年8月~2017年2月120例妊娠高血压患者,将其分为对照组(n=60)与观察组(n=60),对照组予以短效硝苯地平治疗,观察组予以长效硝苯地平治疗,观察两组患者的血压情况、分娩方式、不良反应与新生儿情况。结果治疗前两组患者的血压比较,差异无统计学意义(P>0.05);治疗后,观察组患者的收缩压、舒张压与动脉压更趋于平稳,分别为(121.5±11.4)mm Hg、(81.6±7.4)mm Hg与(96.2±5.7)mm Hg,明显低于对照组患者的(153.9±10.7)mm Hg、(92.1±7.3)mm Hg与(117.5±6.3)mm Hg;观察组患者的顺产率为80.00%,明显高于对照组患者的35.00%,其剖宫产率为20.00%,明显低于对照组患者的65.00%,其新生儿的窘迫与死亡率分别为3.33%与0,明显低于对照组患者的26.67%与8.33%,二者比较差异有统计学意义(P<0.05);两组患者均未出现任何不良反应。结论使用长效硝苯地平治疗妊娠高血压将获得良好的治疗效果,不仅能平稳患者的血压,同时能够提升患者的顺产率,并确保新生儿具有良好的情况,降低其窘迫率与死亡率,具有较高的临床推广价值。

Objective To compare and analyze the clinical effect of short effect and long effect nifedipine in the treatment of pregnancy induced hypertension.Methods One hundred and twenty cases of pregnancy induced hypertension from August2015to February2017were randomly selected and divided into the control group(n=60)and the observation group(n=60).The control group was given short acting nifedipine,the observation group was given long-acting nifedipine treatment,and the blood pressure,delivery mode,adverse reactions and neonates were observed in the two groups.Results There was no significant difference in blood pressure between the two groups before treatment,and the difference was not statistically significant(P>0.05);After treatment,the systolic pressure,diastolic pressure and arterial pressure were more stable in the observation group,and were(121.5±11.4)mm Hg,(81.6±7.4)mm Hg and(96.2±5.7)mm Hg,respectively,which were significantly lower than(153.9±10.7)mm Hg(92.1±7.3)mm Hg and(117.5±6.3)mm Hg in the control group;The rate of delivery in the observation group was80.00%,which was significantly higher than35.00%of the control group,the rate of cesarean section in the observationgroup was20.00%,which was significantly lower than that of the control group of65.00%.The neonatal distress and mortality in the observation group were3.33%and0,respectively,which were significantly lower than those in the control group(26.67%and8.33%).The difference between the two groups was statistically significant(P<0.05);No adverse reaction was found in all two groups.Conclusion The use of long-acting nifedipine in the treatment of pregnancy induced hypertension will get good treatment effect,not only can smooth the blood pressure of the patients,and can improve patient's birth rate,and ensure that the newborn has a good situation,reduce the distress rate and mortality,with higher clinical value of popularization.