经尿道前列腺电切术联合药物去势治疗晚期前列腺癌的临床效果观察

Clinical observation of transurethral resection of the prostate and drug therapy in the treatment of advanced prostate cancer

目的观察前列腺癌晚期患者实施经尿道前列腺电切术联合药物去势治疗的临床效果。方法选取2012年7月~2014年2月期间我院住院部收治的86例前列腺癌晚期患者,根据治疗方案的不同将患者分为治疗组和对照组,其中43例予以经尿道前列腺电切术治疗作为对照组,另43例予以经尿道前列腺电切术联合内分泌药物治疗作为治疗组;观察两组患者治疗前后各指标变化、不良反应及三年生存率等情况。结果两组治疗前各相关指标比较差异无统计学意义(P>0.05);治疗后治疗组PSA水平、IPSS评分及残余尿量均显著低于对照组,治疗组QOL评分与最大尿流量均显著高于对照组,差异有统计学意义(P<0.05);治疗组治疗后1年、2年、3年生存率100.0%、93.0%、76.7%分别高于对照组86.0%、69.8%、48.8%,差异有统计学意义(P<0.05)。两组患者治疗期间均未见严重不良反应。结论临床前列腺癌晚期患者予以经尿道前列腺电切术联合内分泌药物去势治疗,能有效改善机体病症,提高三年生存率,安全有效,可在临床推广。

Objective To observe the clinical effect of the combination of transurethral prostate electrotomy combined with the treatment of prostate cancer in patients with advanced prostate cancer.Methods Eighty-six cases with advanced prostate cancer in our hospital from July2012to February2014were selected.According to the different treatment divided the patients into the treatment group and control group,43cases in each group.The related clinical index,adverse event rate and survival rate within3y for two groups were observed.Results Before treatment,the related clinical index for two groups were not significantly different(P>0.05);After treatment,the index of PSA,IPSS points and residual urine volume for treatment group were significantly lower than control group;the QOL points and maximum urine volume for treatment group were significantly higher than control group(P<0.05);After1y,2y and3y of treatment,the survival rate for treatment group(100.0%,93.0%,76.7%)was significantly higher than control group(86.0%,69.8%,48.8%)(P<0.05).During the process,there were no serious adverse reactions.Conclusion The combination of transurethral prostate electrotomy combined with the treatment of prostate cancer in patients,the safe and improved survival rate for three years effective therapy is worthy of clinical promotion.