利福喷汀与利福平治疗肺结核的临床对比分析

Clinical analysis of rifapentine and rifampicin in the treatment of pulmonary tuberculosis

目的:探讨利福喷汀和利福平治疗肺结核的效果。方法:收治肺结核患者20例,随机分为观察组和对照组,各10例。观察组和对照组分别在常规治疗的基础上联合施利福喷汀胶囊和利福平片治疗。结果:观察组临床治疗总有效率明显高于对照组(P<0.05);在治疗3、6个月期间,观察组痰涂片转阴率、空洞消失率和病灶吸收率明显高于对照组(P<0.05);观察组的胃肠道反应、白细胞减少情况、谷氨酸氨基转移酶和天冬氨酸氨基转移酶水平明显优于对照组(P<0.05)。结论:与利福平相比,利福喷汀治疗肺结核的临床效果更为显著,不良事件发生率较低,且患者满意度高。

Objective:To investigate the effect of rifapentine and rifampicin in the treatment of pulmonary tuberculosis.Methods:20 cases of pulmonary tuberculosis were selected,and divided into the observation group and the control group,with 10 cases in each group.The observation group and the control group were given rifapentine capsules and rifampicin tablets respectively combined with conventional treatment.Results:Clinical efficiency of the observation group was significantly higher than the control group(P<0.05);during the 3 and 6 months of treatment,sputum smear negative rate,empty disappearance rate and lesions absorption rate in the observation group were significantly higher than that of the control group(P<0.05);the gastrointestinal reactions,leukocyte reduction condition glutamic acid,ammonia transferase and aspartate aminotransferase levels in the observation group were significantly lower than the control group(P<0.05).Conclusion:Compared with rifampicin,the clinical effect of rifapentine in the treatment of pulmonary tuberculosis is more significant,the incidence of adverse events was low,and patient satisfaction was higher.