2型糖尿病住院患者胰岛素泵短期应用的胰岛素剂量特点研究

Optimum dose of insulin in short-term application of insulin pump for hospitalized patients with type 2 diabetes mellitus

目的研究住院2型糖尿病患者胰岛素泵短期应用的胰岛素剂量特点。方法将住院且使用胰岛素泵治疗的243例2型糖尿病患者随机分成3组各81例,分别使用不同餐前量和基础量比例治疗;比较各组血糖达标时间、达标时平均胰岛素剂量以及低血糖事件等。结果基础量为主起始组(Ba组)的血糖达标时间、血糖达标时日胰岛素用量、低血糖发生率均明显少于餐前量为主起始组(Bo组)、基础-餐前起始组(Ba-Bo组),差异均有统计学意义(P<0.05)。结论住院2型糖尿病患者使用胰岛素泵治疗具有良好效果,当起始胰岛素泵治疗时基础量占总剂量的60%时,可以缩短血糖达标时间,减少血糖达标时胰岛素总剂量,低血糖风险低。

Objective To determine the optimum dose of insulin in short-term application of insulin pump for hospitalized patients with type2diabetes mellitus.Method243hospitalized patients with type2diabetes mellitus were randomly divided into three groups and were treated with different ratio of pre-dinner and basic quantities respectively.The blood glucose compliance time,the average standard insulin dose and the hypoglycemic events for the three groups were then compared.Findings The blood glucose level,daily insulin dosage as the blood glucose level reaches the standard,and the incidence of hypoglycemia in the Ba group were significantly lower than those in the Bo group and Ba-Bo group.The differences were significant(P<0.05).Conclusion Insulin pump treatment has a desirable effect on hospitalized patients with type2diabetes.When the base amount is set as60%of the total dose in initial insulin pump treatment,it can shorten the blood glucose compliance time,reduce the total dose of insulin as blood glucose reaches the standards and decrease the risk of hypoglycemia.