颈动脉粥样硬化超声检查在睡眠不足人群中的临床意义

Clinical significance of ultrasound of carotid atherosclerosis in patients with sleep deprivation

目的探讨颈动脉粥样硬化超声检查在睡眠不足人群中的临床意义。方法选取行颈动脉超声检查的研究对象共60名,根据研究对象的睡眠情况,将每日睡眠时间<7 h的研究对象纳入观察组,而将每日睡眠时间≥7 h的研究对象纳入对照组。运用多普勒超声检测仪对研究对象进行颈动脉超声检查,比较2组的颈动脉内-中膜厚度、血流动力学参数[包括收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)及血管阻力指数(RI)]和动脉弹性功能参数[包括壁运动度(△D)、僵硬度指数(β)和扩张系数(Dc)]。结果观察组的颈总动脉内-中膜厚度大于对照组(t=2.835,P=0.006),RI高于对照组(t=5.537,P<0.001),2组比较差异有统计学意义。观察组PSV和EDV低于对照组(t值分别为8.935、4.528,P均<0.001),而Ds、Dd和β均大于对照组(t值分别为2.215、2.165、2.052,P均<0.05)。观察组△D和Dc均低于对照组,2组比较差异均有统计学意义(t=2.487,P<0.05和t=5.318,P<0.001)。结论长期睡眠不足人群的颈动脉粥样硬化超声指标与睡眠充足人群存在一定差异,该类人群发生动脉粥样硬化风险可能较高。

Objective To explore the clinical significance of ultrasound of carotid atherosclerosis in patients with sleep deprivation Methods A total of60subjects receiving ultrasound of common carotid artery were recruited in this study.Based on the sleep quality,they were divided into the observation group(daily sleep time<7h)and control group(daily sleep time≥7h[BF])[BFQ].The ultrasound of the common carotid artery was performed by Doppler ultrasonic detector.The carotid artery wall intima-media thickness,hemodynamic parameters[peak systolic velocity(PSV),end diastolic velocity(EDV)and resistance index(RI)]and arterial elastic function indexes[wall motion(△D),wall stiffness(β)and distensibility coefficient(Dc)]Results[WTBZ]In the observation group,the carotid artery wall intima-media thickness was significantly larger(t=2.835,P=0.006)and the RI was considerably higher(t=5.537,P<0.001)compared with those in the control group.In the observation group,PSV(t=8.935,P<0.001)and EDV(t=4.528,P<0.001)were significantly slower,whereas Ds(t=2.215,P<0.05),Dd(t=2.165,P<0.05)andβ(t=2.052,P<0.05)were significantly larger than those in the control group.In the observation group,△D(t=2.487,P<0.05)and Dc(t=5.318,P<0.001)were dramatically lower than those in the control group.Conclusions The ultrasound indexes of carotid atherosclerosis differ between patients with and without sleep deprivation.Patients with sleep deprivation have a higher risk of carotid atherosclerosis compared with their counterparts with sufficient sleep.