C反应蛋白与降钙素原检测对小儿重症肺炎的疗效分析

Analysis on the efficacy of C-reactive protein and procalcitonin determination in pediatric severe pneumonia

目的研究C反应蛋白(CRP)与降钙素原(PCT)检测对小儿重症肺炎的疗效评估。方法研究对象选取2016年1月~2017年4月间我院收治的96例重症肺炎患儿设为观察组,选取同期健康儿童100例作为对照组,采用散射比浊法测量患儿的血浆CRP水平,采用电化学发光法测定PCT水平,对比两组CRP及PCT水平差异,根据疗效将观察组患儿分为治愈组和未治愈组,对比两组患儿的CRP、PCT水平差异,根据存活患儿的疗效情况绘制ROC曲线。结果观察组CRP及PCT水平均显著高于对照组,差异有统计学意义(P<0.05);治愈组患儿的CRP、PCT水平显著低于未治愈组,差异有统计学意义(P<0.05);两种检验指标对病情预后评估的ROC曲线分析显示,CRP联合PCT检测的ROC下面积要显著高于CRP、PCT单独检测,差异有统计学意义(P<0.05)。结论 C反应蛋白和降钙素原是评估小儿重症肺炎疗效及预后的重要指标,联合检测能够提高预测价值,值得在临床上推广和应用。

Objective To investigate the evaluation efficacy of C-reactive protein(CRP)and procalcitonin(PCT)determination in pediatric severe pneumonia.Methods96children patients with severe pneumonia who were admitted to our hospital from January2016to Apirl2017were selected as observation group.100healthy children were selected as the control group.Plasma CRP levels were measured by scatter turbidimetry,the electrochemical luminescence method was used to determine the level of PCT,and the differences of CRP and PCT levels between the two groups were compared.According to the efficacy,the children patients in the observation group were divided into cure group and non-cure group.The differences of CRP and PCT levels were compared between the two groups.ROC curves were drawn based on the efficacy of surviving children patients.Results The levels of CRP and PCT in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of CRP and PCT in the cure group were significantly lower than those in the non-cure group,and the differences were statistically significant(P<0.05);the ROC curve analysis of the two test indicators on the evaluation of prognosis showed that the area under ROC in the determination of CRP combined with PCT was significantly higher than that in the determination of CRP and PCT alone,and the difference was statistically significant(P<0.05).Conclusion C-reactive protein and procalcitonin are important indices in the evaluation of the efficacy and prognosis of pediatric severe pneumonia.Combined determination can improve the predictive value,which is worthy of clinical promotion and application.