建立新的可预测成年终身高及青春期进程的模型及其在特发性中枢性性早熟女童中的应用

Establishment of a new predictable model of adult final height and puberty progess and its application in the grils with idiopathic central precocious puberty

目的探讨建立新的可预测成年终身高及青春期进程的模型及其在特发性中枢性性早熟女童中的应用。方法通过对2005年1月1日~2015年12月31日在我院治疗并随访至成年身高的特发性中枢性性早熟女性患儿进行召回。符合ICPP资料齐全的患儿共303例,正规接受Gn RHa治疗共253例,未接受治疗共50例。将253例治疗组患者根据首次治疗年龄分为低年龄组A组:治疗时间≤7岁及高年龄组B组:治疗时间>7岁,共211例,其中B1考虑快速进展型(LH>10.05或LH峰值/FSH峰值>0.6)共159例,B2考虑非快速进展型共52例。未治疗组C组,共50例。比较各组身高改善情况。结果 Gn RHa治疗组较未治疗组最终身高有改善,差异有统计学意义(P<0.05)。A组予Gn RHa治疗身高改善更明显,差异有统计学意义(P<0.05)。B1快速进展型予Gn RHa治疗身高改善更明显,差异有统计学意义(P<0.05)。结论应用Gn RHa治疗特发性中枢性性早熟对于预测成年终身高疗效确切,尤其对于低年龄、快速进展型效果更好。

Objective To explore the establishment of a new predictable model of adult final height and puberty progress and its application in the girls with idiopathic central precocious puberty.Methods The girls with idiopathic central precocious puberty who were treated and followed up until the adult height in our hospital from January1,2005to December31,2015were recalled.There were303cases of girls in line with complete ICPP data.A total of253patients were formally given GnRHa therapy,a total of50patients did not receive treatment.According to the initial treatment age,253patients in the treatment group were divided into the lower age group A:treatment time was≤7years old,and higher age group B:treatment time was>7years old,with a total of211cases.Group B1considered rapid progress(LH>10.05or LH peak/FSH peak>0.6),with a total of159cases.Group B2considered non-rapid progress,with a total of52cases.Untreated group was group C,with a total of50cases.The height improvement in each group was compared.Results The final height of the girls receiving GnRHa treatment group was improved compared with the untreated group,and the difference was statistically significant(P<0.05).Group A was given GnRHa treatment,and the height improvement was more obvious.The difference was statistically significant(P<0.05).B1rapid progress group was given GnRHa treatment and the height improvement was more obvious.The difference was statistically significant(P<0.05).Conclusion The application of GnRHa in the treatment of idiopathic central precocious puberty has an exact effect on predicting adult final height,especially for lower age and rapid progress,which has a better effect.