LC治疗急性结石性胆囊炎合并胆汁性腹膜炎疗效观察

Curative Observation of LC on the Treatment of Acute Calcific Cholecystitis Combined with Biliary Peritonitis

目的探讨腹腔镜胆囊切除术(LC)与开腹胆囊切除术(OC)对急性结石性胆囊炎合并胆汁性腹膜炎患者机体内炎症性免疫反应的影响.方法分析136例急性结石性胆囊炎患者的临床资料,将入选者随机分成观察组(LC治疗)和对照组(OC治疗)两组,每组68例.比较两组患者的一般资料、临床症状及手术前后的炎性因子水平.结果两组患者的一般资料差异无统计学意义(P>0.05).观察组患者的住院时间、术后死亡率及并发症发生率均明显低于对照组(P<0.05).术前两组患者的炎性指标水平差异无统计学意义(P>0.05);术后两组患者的各炎性指标比较差异具有统计学意义(P<0.05).结论与OC相比,LC可有效降低急性结石性胆囊炎合并胆汁性腹膜炎患者的炎性反应,有助于患者快速建立免疫防御系统.

Objective To analyze the influences of LC and OC on the inflammatory reaction and immune response in the patients with acute calculous cholecystitis combined with bile peritonitis.Method The clinical datum of136patients with acute calculous cholecystitis received treatment was retrospectively analyzed.The patients were randomly divided into two groups,the observe group(LC treatment)and the control group(OC treatment).The general information,clinical symptoms and the levels of inflammatory factors before and after operation in two groups were compared.Results The general information of the two groups had no statistical difference(P>0.05).The length of stay,postoperative mortality and the incidence of complications of the observe group were obviously lower than those of the control group(P<0.05).The levels of the inflammatory factors before operation in the two groups had no statistical difference(P>0.05).But the postoperative levels of the two groups showed statistical difference(P<0.05).Conclusion Compared to OC,LC could significantly decrease the immune response in the acute calculous cholecystitis patients combined with bile peritonitis,which is helpful for establishing the immune system rapidly.