经颅直流电刺激治疗CO中毒后认知功能障碍观察

Therapeutic effect of transcranial direct current stimulation on cognitive dysfunction following acute CO poisoning

目的:探讨经颅直流电刺激(transcranial direct current stimulation,t DCS)治疗急性CO中毒患者认知功能障碍的疗效。方法:选取15例CO中毒后认知功能障碍患者,对患者均进行常规康复治疗和t DCS治疗,治疗前后采用简易精神状态评价(minimum mental state examination,MMSE)量表、上肢反应时间及事件相关电位P300综合评估患者认知功能情况。结果:与治疗前相比,常规康复治疗和t DCS治疗后患者MMSE评分明显升高,上肢反应时间明显缩短且正确率显著升高,P300检测中P3波潜伏期明显缩短,波幅显著升高,差异均有统计学意义(P<0.05或P<0.01)。结论:t DCS有助于提高急性CO中毒患者认知功能。

Objective:To investigate the therapeutic effect of transcranial direct current stimulation on cognitive dysfunction in patients with acute CO poisoning.Methods:Fifteen patients with cognitive dysfunction following CO poisoning were all treated with routine rehabilitation therapy and transcranial direct current stimulation.The minimum mental state examination scale,reaction time of upper limb and event-related potential were used to comprehensively evaluate the cognitive function before and after treatment.Results:Compared with those before treatment,MMSE scores increased significantly,upper limb reaction time was obviously shortened and the correct rate increased,the latency of P3 wave(P300)was shortened and amplitudes significantly increased,and the differences were all statistically significant(P<0.05 or P<0.01).Conclusion:Transcranial direct current stimulation may be conducive to improve the cognitive function of patients with acute CO poisoning.