恩替卡韦联合微生态制剂对乙肝肝硬化患者肝功能、HBV-DNA和肝纤维化指标的影响

Effects of entecavir combined with micro-ecological preparations on liver function,HBV-DNA and liver fibrosis of patients with hepatitis B cirrhosis

目的探讨恩替卡韦联合微生态制剂对乙肝肝硬化患者症状体征、肝功能、肝纤维化指标及HBV DNA的影响。方法选择接受治疗的乙肝肝硬化患者80例,按随机数表法分为研究组和对照组(n=40)。对照组采用单纯恩替卡韦治疗,研究组采用微生态制剂和恩替卡韦联合治疗。比较2组患者治疗后厌食、乏力及腹胀症状改善情况;比较2组患者治疗前后的肝功能及肝纤维情况;比较2组患者治疗的腹部彩超结果及HBV-DNA治疗的有效率。结果治疗后,研究组患者的厌食、乏力以及腹胀的改善状况明显优于对照组(P<0.05);研究组患者的AST、ALT及TBIL值均低于对照组(P<0.05);研究组患者肝纤维的各项指数均明显低于对照组(P<0.05);研究组的脾脏厚度及门静脉内径明显低于对照组,研究组患者治疗HBV-DNA的有效率为92.50%明显高于对照组的70.00%,差异有统计学意义(P<0.05)。结论恩替卡韦联合微生态制剂治疗乙肝肝硬化能有效改善患者的肝功能,减轻厌食等症状,提高治疗有效率,相较于单纯恩替卡韦治疗更具有临床使用价值。

Objective To investigate the effects of entecavir combined with micro-ecological preparations on the symptoms and signs,liver function,HBV-DNA and liver fibrosis of patients with hepatitis B cirrhosis.Methods Eighty patients with hepatitis B cirrhosis who were treated in our hospital from January 2015 to December 2017 were enrolled in the study,who were divided into study group and control group according to random number table,with 40 patients in each group.The patients in control group were treated by simple entecavir,however,the patients in study group were treated by entecavir combined with micro-ecological preparations.After treatment,the improvement state of patient’s symptoms including anorexia,fatigue and abdominal distention were observed,moreover the liver function and liver fibration indexes before and after treatment were observed and compared between two groups.Besides the examination results by abdominal color Doppler ultrasound and therapeutic effects on HBV-DNA were observed and compared between two groups.Results After treatment,the improvement degree of patient’s symptoms including anorexia,fatigue and abdominal distention in study group was superior to that in control group.The levels of AST,ALT and TBIL in study group were significantly lower than those in control group(P<0.05).The indexes of liver fibrosis in study group were significantly lower than those in control group(P<0.05).Moreover the thickness of spleen and portal vein diameter in study group were significantly lower than those in control group,and the effective rate(92.50%)of treating HBV-DNA in study group was significantly higher than that(70.00%)in control group(P<0.05).Conclusion The entecavir combined with microecological preparation in treatment of hepatitis B liver cirrhosis can effectively improve patient’s liver function,relieve anorexia and the other symptoms,improve therapeutic effects,therefor,which is superior to simple entecavir.