健脾理气方治疗脾虚气滞型功能性消化不良餐后不适综合征45例及对胃肠激素的影响

Clinical Effect of Jianpi Liqi Recipe for Treating Postprandial Distress Syndrome of Functional Dyspepsia with Spleen Deficiency and Qi Stagnation Type in 45 Cases and Its Effect on Gastrointestinal Hormone

目的观察健脾理气方治疗脾虚气滞型功能性消化不良餐后不适综合征的临床疗效及对人体成分和血清胃促生长素(Ghrelin)、降钙素基因相关肽(CGRP)的影响。方法将收治的餐后不适综合征患者90例随机分为两组,各45例,后因脱落3例,最终治疗组44例,对照组43例。治疗组给予健脾理气方,对照组给予常规西药口服,疗程均为4周。结果与对照组相比,治疗组的总有效率更高(81.82%比55.81%),中医症状积分改善更明显(P<0.05);治疗组患者血清Ghrelin水平明显提高,血清CGRP水平下降(P<0.05)。两组人体成分去脂组织指数均较本组治疗前上升(P<0.05)。结论健脾理气方治疗脾虚气滞型功能性消化不良餐后不适综合征,疗效显著,安全有效。

Objective To observe the clinical effect of Jianpi Liqi Recipe for treating postprandial distress syndrome of functional dyspepsia with spleen deficiency and qi stagnation type and its effect on human body composition and serum Ghrelin and CGRP.Methods Totally 90 patients with postprandial distress syndrome were randomly divided into two groups,45 cases in each group.There were 3 cases of posterior abscission,finally,44 cases in the treatment group and 43 cases in the control group.The treatment group was given Jianpi Liqi Recipe,and the control group was given the routine Western medicine.The two groups were treated for 4 weeks.Results Compared with the control group,the total effective rate in the treatment group were significantly higher(81.82%vs.51.81%,P<0.05),and the TCM symptom score in the treatment group were significantly improved(P<0.05),the serum Ghrelin level in the treatment group was significantly increased,and the serum CGRP level was decreased,the difference was statistically significant(P<0.05).The fat-free mass index(FFMI)in the two groups was higher than that before the treatment(P<0.05).Conclusion Jianpi Liqi Recipe for treating postprandial distress syndrome of functional dyspepsia with spleen deficiency and qi stagnation type has significant effect and it is safe and effective.