1PERDUE M, SUARZE D. Structural features of the avian influenza virus heamagglutinin that influence virulence [J]. Vet Micro, 2000,74:77-86.
2TUMPEY T, MAINES T, VAN H, et al. A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission [ J ]. Science, 2007,315 ( 5812 ) : 655 -659.
3MATROSOVICH M, GAMBARYAN A,TENEBERG S,et al. Avian influenza A viruses differ from human viruses by recognition of sialyloligosaccharides and gangliosides and by a higher conservation of the HA receptor-binding site[J]. Virology, 1997, 233 ( 1 ) : 224-234.
4GAO Y, ZHANG Y, SHINYA K, et al. Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host[J]. PLoS Pathog,2009,5 (12):e1000709.
5QI W, TIAN J, SU S, et al. Identification of potential virulence determinants associated H9N2 avian influenza virus PB2 E627K mutation by comparative proteomics[Jl. Proteomics,2015, 15(9) : 1512-1524.
6BUSSEY K,BOUSSE T,DESMET E,et al. PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells[J]. J Virol, 2010, 84(9): 4395-406.
7MEHLE A, DOUDNA J. An inhibitory activity ceils restricts the function of an avian-like influenza merase[J]. Cell Host Microbe,2008,4(2) : 111-122.
8YAMADA S, HATTA M, STAKER B.L,et al. Biological and structural characterization of a host-adapting amino acid in influenza virus[J]. PLoS Pathog,2010,6(8):e1001034.
9FAUCI A S. Emerging and re-emerging infectious diseases: influenza as a prototype of the host-pathogen balancing act[J]. Cell, 2006,124(4) : 665-670.
10DESSELBERGER U, NAKAJIMA K, ALFINO P, et al. Biochemical evidence that new influenza virus strains in nature may arise by recombination (reassortment)[J]. Proc Natl Acad Sci, 1978,75(7) :3341-3345.