基于肺与大肠相表里的肺病患者肠道便菌群特点研究

Study on Intestinal Flora Feature of Lung Diseases Patients Based on Lung and Large Intestine Being Interior-Exteriorly Related Theory

目的探讨肺病患者与非肺病患者便球杆菌群特点,为肺肠同治提供临床依据。方法采用横断面调查法,将112例患者分为肺病组47例和非肺病组65例,对患者进行问卷调查,包括一般人口学资料、肺系疾病及病程、非肺系疾病及病程、用药、饮食、睡眠、情志、体力及大便情况。采集粪便标本,行涂片法检测球杆菌比值。结果肺病组、非肺病组分别脱落3、5例。肺病组球杆比平均值为0.78,非肺病组为0.35,2组比较差异有统计学意义(P=0.041);肺病组革兰阴性杆菌平均值为56.59%,非肺病组为65.50%,2组比较差异有统计学意义(P=0.040);肺病组革兰阳性球菌平均值为33.52%,非肺病组为23.80%,2组比较差异有统计学意义(P=0.004);肺病组革兰阴性杆菌异常型23例,非肺病组44例,2组比较差异有统计学意义(P=0.038);肺病组纳差21例,非肺病组14例,2组比较差异有统计学意义(P=0.012);肺病组便秘23例,非肺病组19例,2组比较差异有统计学意义(P=0.044);肺病组便溏15例,非肺病组9例,2组比较差异有统计学意义(P=0.033)。结论肺病患者存在肠道菌群失调,有明显的纳差、便秘、便溏,存在肺肠同病趋势,基于肺与大肠相表里的肺肠同治具有一定临床意义。

Objective To discuss the stool coccobacillus flora features between lung diseases patients and non-lung diseases patients for confirming homotherapy for the lung and the large intestine ideology based on the lung and large intestine being interior-exteriorly related theory.Methods Totally112patients were divided into lung diseases group(47cases)and non-lung diseases group(65cases)by cross-sectional study.Questionnaire survey for patients was used,including general demographic information,lung diseases and course of disease,non-lung diseases and course of disease,medication,diet,sleep,emotional,physical and stool.Stool specimens were collected and smear method was used to detect the ratio of coccus.Results3cases were lost in the lung diseases group and5cases were lost in the non-lung diseases group.Stool coccobacillus mean proportionality was0.78in lung diseases group,and0.35in non-lung diseases group,with statistical significance(P=0.041).Stool gram negative bacilli mean value was56.59%in lung diseases group,and65.50%in non-lung diseases group,with statistical significance(P=0.040).Stool gram positive coccus mean value was33.52%in lung diseases group,and23.80%in non-lung diseases group,with statistical significance(P=0.004).There were23cases of stool gram negative bacilli aberrant type in lung diseases group,and44cases in non-lung diseases group,with statistical significance(P=0.038).There were21cases of loss of appetite in lung diseases group,and14cases in non-lung diseases group,with statistical significance(P=0.012).There were23cases of constipation in lung diseases group,and19cases in non-lung diseases group,with statistical significance(P=0.044).There were15cases of loose stool in lung diseases group,and9cases in non-lung diseases group,with statistical significance(P=0.033).Conclusion Lung diseases patients occur to alteration of intestinal flora potentially.And symptoms include loss of appetite,constipation,loose stool,which occur to lung diseases patients significantly,indicating lung and large intestine tend to exist homopathy.It is important to homotherapy for the lung and the large intestine based on the lung and the large intestine being interior-exteriorly related.