多指标综合评分法优选芩蒿滴鼻剂提取工艺

Optimization of Extraction Technology for Qinhao Nasal Drops by Multi-index Comprehensive Evaluation Method

目的探讨多指标综合评分法优选芩蒿滴鼻剂的提取工艺。方法采用L_9(3~4)正交设计,以一枝蒿酮酸、绿原酸、盐酸伪麻黄碱、总黄酮含量及出膏率的综合评分为考察指标,优选芩蒿滴鼻剂的提取工艺。结果最佳提取工艺为:用60%乙醇溶液,加12倍量,提取3次。结论本研究优选出的提取工艺简单、可行,适合大生产需要,可作为该制剂合理开发的依据。

Objective To optimize extraction process of Qinhao Nasal Drops by multi-index comprehensive evaluation Method.Methods With L9(34)orthogonal design,the content of rupestonic acid,chlorogenic acid,pseudoephedrine hydrochloride,total flavonoids and extract yield were set as indexes,and extraction technology of Qinhao Nasal Drops was optimized.Results Optimum extraction technology was:12times amount of60%ethanol,extracted three times.Conclusion The optimized extraction technology is simple,practical,and adapt to the production needs,which can be used as the basis for reasonable development of the preparation.