高强度间歇运动对2型糖尿病干预效果的Meta分析

Effects of High Intensity Interval Training on Type 2 Diabetes Mellitus: A Meta-analysis

目的评价高强度间歇运动(HIIT)对2型糖尿病(T2DM)患者的干预效果。方法检索Pub Med、Embase、Cochrane Library、EBSCO、Web of Science、中国知网(CNKI)和中国生物医学文献数据库(CBM)中关于HIIT干预T2DM患者疗效的随机对照试验,搜索时限从建库至2017年9月1日。由两名研究者按纳入和排除标准筛选文献并提取有效数据,进行质量评价。采用Rev Man 5.3软件对最终纳入的文献数据进行Meta分析。结果最终纳入8篇文献,共275例受试者。HIIT在改善T2DM患者糖化血红蛋白(SMD=-0.72,95%CI-1.39^-0.04,P=0.04)以及体质量指数(MD=-0.60,95%CI-1.03^-0.18,P=0.005)方面优于对照组,对空腹血糖、空腹血胰岛素、胰岛素抵抗、血脂相关指标、体质量、体脂含量以及腰围等的干预效应与对照组无显著性差异(P>0.05)。结论 HIIT在改善T2DM患者血糖调节能力、血脂和体成分方面,未有证据显示其作用优于对照组,需要进一步研究。

Objective To evaluate the effect of high intensity interval training(HIIT)on type2diabetes mellitus(T2DM).Methods Published articles from the earliest date available to September the first,2016were recalled from PubMed,Embase,Cochrane Library,EBSCO,Web of Science,CNKI and CBM Database.Two reviewers selected independently the randomized controlled trials(RCTs)about HIIT for patients with T2DM,and extracted data independently and analyzed with RevMan5.3.Results Eight trials that represented275participants were evaluated.HIIT could significantly improve glycated hemoglobin(SMD=-0.72,95%CI-1.39^-0.04,P=0.04)and body mass index(MD=-0.60,95%CI-1.03^-0.18,P=0.005)more than the control group,but no difference was found in the levels of fasting blood-glucose,fasting insulin,insulin resistance,and indexes of blood fat,body mass,body fat mass and waist circumference(P>0.05).Conclusion There is no evidence showed that HIIT is more effective on blood glucose,blood fat and body composition in the patients with T2DM,which needs further research.