妇幼医院163例药品不良反应报告分析

Analysis of Adverse Drug Reaction in 163 Cases of Women and Children Hospital

目的了解妇女儿童药物不良反应(ADR)的特点,为妇女儿童用药安全提供参考。方法对某妇幼医院2016年的163例ADR进行分析与统计。结果 163例报告中,1~6岁ADR发生率最高,占53.38%;静脉点滴给药发生的ADR最多,占84.05%;头孢类及青霉素类抗菌药物ADR居多,占69.33%;累及的器官或系统以皮肤系统损害最多见,占78.53%;严重ADR发生率最高的为人流药米索前列醇片,占严重ADR的37.5%,易忽视的小儿氨基酸注射液、头孢克洛咀嚼片发生了严重ADR。结论妇女儿童应慎用静脉给药,合理使用抗菌药物以减少ADR发生,同时加强药学监护,及时发现ADR并处理。

Objective To understand the characteristics of adverse drug reactions(ADR)in women and children,and to provide references for the safety of drug use for women and children.Methods Retrospective analysis and statistics were made on163cases of ADR reported in women's and children's hospital in2016.Results Report of163cases of1-6years old,ADR was the highest,accounting for53.38%;intravenous administration of ADR at most,accounting for84.05%;cephalosporins and penicillin antibiotics ADR majority,accounting for69.33%;involving the organs or systems to the skin system damage the most common,accounting for78.53%;the highest incidence of severe ADR oral misoprostol tablets,accounting for serious ADR37.5%,Easy to overlook children with amino acid injection,cefaclor chewable tablets had a serious ADR.Conclusion Women and children should be careful with intravenous administration,rational use of antimicrobial drugs to reduce the occurrence of ADR,while strengthening pharmaceutical care,timely detection and treatment of ADR.