免疫学检验联合检测在诊断类风湿关节炎诊断中的有效应用

Combined application of immunoassay in the diagnosis of rheumatoid arthritis

目的探讨免疫学检验联合检测对于类风湿关节炎诊断的临床应用价值。方法选取2015年10月~2017年2月期间本院收治的48例类风湿性关节炎患者作为观察组,另选择同期在本院体检的48例健康者作为对照组。两组受试者分别进行类风湿因子(RF)、抗环瓜氨酸多肽抗体(抗CCP)、免疫球蛋白G(Ig G)、补体C3和C4等免疫学指标检测,比较两组检测结果。结果观察组RF、抗CCP指标水平显著高于对照组,组间差异有统计学意义(P<0.05);观察组RF、抗CCP指标阳性率显著高于对照组,组间差异有统计学意义(P<0.05)。观察组Ig G指标水平显著高于对照组,组间差异有统计学意义(P<0.05);观察组补体C3和C4指标水平均显著低于对照组,组间差异有统计学意义(P<0.05)。结论类风湿关节炎临床诊断中联合检测免疫学指标检测有助于提高诊断准确性。

Objective To investigate the clinical value of combined immunoassay in the diagnosis of rheumatoid arthritis.Methods From October2015to February2017,48patients with rheumatoid arthritis in our hospital were selected as the observation group,and48cases of non rheumatoid arthritis patients in the same period as the control group were selected as the control group.Two groups of subjects were performed separately.Rheumatoid factor(RF),anti cyclic citrullinated peptide antibodies(anti CCP),immunoglobulin G(IgG),complement C3and C4and other immunological indexes were detected,and the results of the two groups were compared.Results The levels of RF and anti CCP in the observation group were significantly higher than those in the control group(P<0.05).The positive rate of RF,anti CCP and AKA indexes in the observation group was significantly higher than that in the control group,the difference between the two groups(P<0.05).The level of IgG index in the observation group was significantly higher than that in the control group(P<0.05).The levels of complement C3and C4in the observation group were significantly lower than those in the control group(P<0.05).Conclusion The combined detection of immunological markers in the clinical diagnosis of rheumatoid arthritis is helpful to improve the diagnostic accuracy.