高龄患者应用右美托咪定麻醉的效果观察

Clinical anesthesia effect of Dexmedetomidine in elderly patients

目的观察高龄患者应用右美托咪定麻醉的效果。方法选取2016年1月~2017年6月于本院进行治疗的120例行腹腔镜胃癌根治术的高龄患者,随机分为观察组和对照组,各60例,对照组采用异丙酚+地氟烷维持麻醉,观察组采用右美托咪定+地氟烷维持麻醉方式,观察两组患者麻醉效果。结果麻醉诱导后(T2)至手术开始30 min(T5)阶段,两组患者血压均明显下降,与T1相比,差异有统计学意义(P<0.05)。观察组血压、心率在麻醉诱导、气管插管以及苏醒拔管时变化幅度较对照组小,循环更趋于平稳,差异有统计学意义(P<0.05)。观察组的不良反应发生率(3.3%)明显小于对照组(11.6%),差异有统计学意义(P<0.05)。结论高龄患者应用右美托咪定麻醉,能够明显增加血流动力学稳定性,减少术后不良反应发生率,值得临床推广。

Objective To observe the clinical anesthesia effect of Dexmedetomidine in elderly patients.Methods120elderly patients of receiving the anesthesia from January2016to June2017in our hospital were selected.The subjects were randomly divided into two groups,60cases each group.The control group took Propofol+Desflurane for maintenance of anesthesia;the observation group took Dexmedetomidine+Desflurane for maintenance of anesthesia.Results From anesthesia induction(T2)to30min of surgery(T5),The variation range of blood pressure and heart rate in the observation group was lower than the control group during anesthesia,and the circulation was more stable(P<0.05);the adverse event rate for observation group(3.3%)was significantly lower than control group(11.6%)(P<0.05).Conclusion For elderly patients,Dexmedetomidine can greatly improve the hemodynamics stability and reduce the incidence rate of postoperative adverse reactions.It is worthy of clinical promotion.